Mechanisms of HIV transmission in Depo-Provera users: The likely role of Hypoestrogenism

Martha Hickey, Jennifer L. Marino, Gilda Tachedjian

Research output: Contribution to journalScientific ReviewResearchpeer-review

12 Citations (Scopus)


Almost half of new HIV infections worldwide occur in women, and vaginal intercourse is the most common mode of transmission. Accumulating evidence suggests that depot medroxyprogesterone acetate may increase HIV transmission, but little is known about the underlying mechanisms. We propose that hypoestrogenism in depot medroxyprogesterone acetate may contribute to increased HIV transmission. We present supportive evidence and propose potential interventions to prevent or treat vaginal hypoestrogenism using vaginal estrogens.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
Issue number1
Publication statusPublished - 1 Jan 2016


  • HIV transmission
  • hypoestrogenism
  • Depo-Provera
  • vaginal estrogen

Cite this