TY - JOUR
T1 - Mechanisms and Control of Impurities in Continuous Crystallization
T2 - A Review
AU - Darmali, Christine
AU - Mansouri, Shahnaz
AU - Yazdanpanah, Nima
AU - Woo, Meng W.
PY - 2019/1/30
Y1 - 2019/1/30
N2 - Crystallization has been applied to a broad range of industries such as bulk and fine chemicals and the pharmaceutical and food industries. It is important to strategically control the in situ purification process during crystallization to meet the regulatory and functional specifications of the crystals. While the control of the crystallization-purification process has been widely discussed for batch crystallizers, there has been little focus with the literature on controlling purification for continuous crystallizers. Continuous crystallization is a more intensified approach to crystallization, with lower capital footprint and potentially offering more consistent quality control. This review paper provides an in-depth discussion of the strategies and scientific understanding in controlling the crystallization-purification process in continuous crystallization. In particular, it describes how scientific understanding in the purification process, generated so far for batch crystallization, can be translated to continuous crystallization.
AB - Crystallization has been applied to a broad range of industries such as bulk and fine chemicals and the pharmaceutical and food industries. It is important to strategically control the in situ purification process during crystallization to meet the regulatory and functional specifications of the crystals. While the control of the crystallization-purification process has been widely discussed for batch crystallizers, there has been little focus with the literature on controlling purification for continuous crystallizers. Continuous crystallization is a more intensified approach to crystallization, with lower capital footprint and potentially offering more consistent quality control. This review paper provides an in-depth discussion of the strategies and scientific understanding in controlling the crystallization-purification process in continuous crystallization. In particular, it describes how scientific understanding in the purification process, generated so far for batch crystallization, can be translated to continuous crystallization.
UR - http://www.scopus.com/inward/record.url?scp=85060914563&partnerID=8YFLogxK
U2 - 10.1021/acs.iecr.8b04560
DO - 10.1021/acs.iecr.8b04560
M3 - Article
AN - SCOPUS:85060914563
VL - 58
SP - 1463
EP - 1479
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
SN - 0888-5885
IS - 4
ER -