Mechanism of hydrolysis of a platinum(IV) complex discovered by atomic telemetry

Joanna Czapla-Masztafiak; Adam Kubas; Yves Kayser; Daniel L.A. Fernandes; Wojciech M. Kwiatek; Ewelina Lipiec; Glen B Deacon; Khansa  Al-Jorani; Bayden R. Wood; Jakub Szlachetko; Jacinto Sa

doi:10.1016/j.jinorgbio.2018.07.012

Mechanism of hydrolysis of a platinum(IV) complex discovered by atomic telemetry

Joanna Czapla-Masztafiak, Adam Kubas, Yves Kayser, Daniel L.A. Fernandes, Wojciech M. Kwiatek, Ewelina Lipiec, Glen B Deacon, Khansa Al-Jorani, Bayden R. Wood, Jakub Szlachetko, Jacinto Sa

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Herein we report on the hydrolysis mechanism of [Pt{N(p-HC₆F₄)CH₂}₂(NC₅H₅)₂(OH)₂], a platinum(IV) complex that exhibits anti-cancer properties. Atomic telemetry, an in situ technique based on electron structure sensitive X-ray spectroscopy, revealed that hydrolysis preceded any reduction of the metal center. The obtained results are complemented with ¹⁹F NMR measurements and theoretical calculations and support the observation that this Pt^IV complex does not reduce spontaneously to Pt^II in HEPES buffer solution at pH 7.4 and after 24 h incubation. These results are of importance for the design of novel Pt-based coordination complexes as well as understanding their behavior under physiological conditions.

Original language	English
Pages (from-to)	56-61
Number of pages	6
Journal	Journal of Inorganic Biochemistry
Volume	187
DOIs	https://doi.org/10.1016/j.jinorgbio.2018.07.012
Publication status	Published - 1 Oct 2018

Keywords

Anti-cancer Pt complex
Atomic telemetry
Hydrolysis mechanism
In situ measurement

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinorgbio.2018.07.012

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title = "Mechanism of hydrolysis of a platinum(IV) complex discovered by atomic telemetry",

abstract = "Herein we report on the hydrolysis mechanism of [Pt{N(p-HC6F4)CH2}2(NC5H5)2(OH)2], a platinum(IV) complex that exhibits anti-cancer properties. Atomic telemetry, an in situ technique based on electron structure sensitive X-ray spectroscopy, revealed that hydrolysis preceded any reduction of the metal center. The obtained results are complemented with 19F NMR measurements and theoretical calculations and support the observation that this PtIV complex does not reduce spontaneously to PtII in HEPES buffer solution at pH 7.4 and after 24 h incubation. These results are of importance for the design of novel Pt-based coordination complexes as well as understanding their behavior under physiological conditions.",

keywords = "Anti-cancer Pt complex, Atomic telemetry, Hydrolysis mechanism, In situ measurement",

author = "Joanna Czapla-Masztafiak and Adam Kubas and Yves Kayser and Fernandes, {Daniel L.A.} and Kwiatek, {Wojciech M.} and Ewelina Lipiec and Deacon, {Glen B} and Khansa Al-Jorani and Wood, {Bayden R.} and Jakub Szlachetko and Jacinto Sa",

year = "2018",

month = oct,

day = "1",

doi = "10.1016/j.jinorgbio.2018.07.012",

language = "English",

volume = "187",

pages = "56--61",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier",

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TY - JOUR

T1 - Mechanism of hydrolysis of a platinum(IV) complex discovered by atomic telemetry

AU - Czapla-Masztafiak, Joanna

AU - Kubas, Adam

AU - Kayser, Yves

AU - Fernandes, Daniel L.A.

AU - Kwiatek, Wojciech M.

AU - Lipiec, Ewelina

AU - Deacon, Glen B

AU - Al-Jorani, Khansa

AU - Wood, Bayden R.

AU - Szlachetko, Jakub

AU - Sa, Jacinto

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Herein we report on the hydrolysis mechanism of [Pt{N(p-HC6F4)CH2}2(NC5H5)2(OH)2], a platinum(IV) complex that exhibits anti-cancer properties. Atomic telemetry, an in situ technique based on electron structure sensitive X-ray spectroscopy, revealed that hydrolysis preceded any reduction of the metal center. The obtained results are complemented with 19F NMR measurements and theoretical calculations and support the observation that this PtIV complex does not reduce spontaneously to PtII in HEPES buffer solution at pH 7.4 and after 24 h incubation. These results are of importance for the design of novel Pt-based coordination complexes as well as understanding their behavior under physiological conditions.

AB - Herein we report on the hydrolysis mechanism of [Pt{N(p-HC6F4)CH2}2(NC5H5)2(OH)2], a platinum(IV) complex that exhibits anti-cancer properties. Atomic telemetry, an in situ technique based on electron structure sensitive X-ray spectroscopy, revealed that hydrolysis preceded any reduction of the metal center. The obtained results are complemented with 19F NMR measurements and theoretical calculations and support the observation that this PtIV complex does not reduce spontaneously to PtII in HEPES buffer solution at pH 7.4 and after 24 h incubation. These results are of importance for the design of novel Pt-based coordination complexes as well as understanding their behavior under physiological conditions.

KW - Anti-cancer Pt complex

KW - Atomic telemetry

KW - Hydrolysis mechanism

KW - In situ measurement

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U2 - 10.1016/j.jinorgbio.2018.07.012

DO - 10.1016/j.jinorgbio.2018.07.012

M3 - Article

AN - SCOPUS:85050280755

SN - 0162-0134

VL - 187

SP - 56

EP - 61

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Mechanism of hydrolysis of a platinum(IV) complex discovered by atomic telemetry

Abstract

Keywords

UN SDGs

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