Mechanism and catalytic diversity of rieske non-heme iron-dependent oxygenases

Sarah M. Barry; Gregory L. Challis

doi:10.1021/cs400087p

Mechanism and catalytic diversity of rieske non-heme iron-dependent oxygenases

Sarah M. Barry, Gregory L. Challis

Research output: Contribution to journal › Article › Research › peer-review

164 Citations (Scopus)

Abstract

Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.

Original language	English
Pages (from-to)	2362-2370
Number of pages	9
Journal	ACS Catalysis
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/cs400087p
Publication status	Published - 4 Oct 2013
Externally published	Yes

Keywords

amine oxidation
biodegradation
biosynthesis
C-H functionalization
dihydroxylation
oxidative cyclisation

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10.1021/cs400087p

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abstract = "Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.",

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AU - Barry, Sarah M.

AU - Challis, Gregory L.

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N2 - Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.

AB - Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.

KW - amine oxidation

KW - biodegradation

KW - biosynthesis

KW - C-H functionalization

KW - dihydroxylation

KW - oxidative cyclisation

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U2 - 10.1021/cs400087p

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JO - ACS Catalysis

JF - ACS Catalysis

IS - 10

ER -

Mechanism and catalytic diversity of rieske non-heme iron-dependent oxygenases

Abstract

Keywords

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