Mechanism and catalytic diversity of rieske non-heme iron-dependent oxygenases

Sarah M. Barry, Gregory L. Challis

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Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.

Original languageEnglish
Pages (from-to)2362-2370
Number of pages9
JournalACS Catalysis
Issue number10
Publication statusPublished - 4 Oct 2013
Externally publishedYes


  • amine oxidation
  • biodegradation
  • biosynthesis
  • C-H functionalization
  • dihydroxylation
  • oxidative cyclisation

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