Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles

Jiwei Cui, Robert De Rose, James P Best, Angus Johnston, Sheilajen Alcantara, Kang Liang, Georgina Kate Such, Stephen J Kent, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Abstract

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
Original languageEnglish
Pages (from-to)3468 - 3472
Number of pages5
JournalAdvanced Materials
Volume25
Issue number25
DOIs
Publication statusPublished - 2013
Externally publishedYes

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