Mechanical properties of the brain-skull interface

Mohammad Mynuddin Gani Mazumder, Karol Miller, Stuart Bunt, Ahmed Mostayed, Grand Joldes, Robert Day, Robin Hart, Adam Wittek

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Knowledge of the mechanical properties of the brain-skull interface is important for surgery simulation and injury biomechanics. These properties are known only to a limited extent. In this study we conducted in situ indentation of the sheep brain, and proposed to derive the macroscopic mechanical properties of the brain-skull interface from the results of these experiments. To the best of our knowledge, this is the first ever analysis of this kind. When conducting in situ indentation of the brain, the reaction force on the indenter was measured. After the indentation, a cylindrical sample of the brain tissue was extracted and subjected to uniaxial compression test. a model of the brain indentation experiment was built in the Finite Element (FE) solver ABAQUS™. In the model, the mechanical properties of the brain tissue were assigned as obtained from the uniaxial compression test and the brain-skull interface was modeled as linear springs. The interface stiffness (defined as sum of stiffness of the springs divided by the interface area) was varied to obtain good agreement between the calculated and experimentally measured indenter force-displacement relationship. Such agreement was found to occur for the brain-skull interface stiffness of 11.45 Nmm-1/mm2. This allowed identification of the overall mechanical properties of the brain-skull interface.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalActa of Bioengineering and Biomechanics
Volume15
Issue number2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Biomechanics
  • Brain-skull
  • FEM
  • Interface
  • Mechanical properties

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