Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC

Ingo Ahrens, Jonathon Habersberger, Nadege Baumlin, Hongwei Qian, Belinda Smith, Johannes-Peter Stasch, Christoph Bode, Harald Schmidt, Karlheinz Peter

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

The soluble guanylate cyclase (sGC) activator Cinaciguat (BAY 58-2667) represents a novel class of drugs that selectively activate oxidised sGC. The extent of oxidised sGC depends on the patienta??s oxidative burden. We here describe two platelet-based assays that allow determining the extent of oxidised sGC and thus provide a basis for an individualised pharmacotherapy
Original languageEnglish
Pages (from-to)431 - 434
Number of pages4
JournalAtherosclerosis
Volume218
Issue number2
DOIs
Publication statusPublished - 2011

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