Measurement of vapor pressure and viscosity of ethanol in HFA134a, HFA152a, and HFO1234ze(E) mixtures used in pMDIs

Swetha Vutlapalli, Lingzhe Rao, Benjamin Myatt, Phil Cocks, Stephen Stein, Hui Xin Ong, Paul Young, Damon Honnery, Daniel J. Duke

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


The replacement of current generation HFA propellants with low global warming potential (GWP) alternatives such as HFA152a and HFO1234ze(E) in solution based pressurized metered-dose inhaler (pMDIs) is not straightforward due to a lack of thermophysical property data for binary mixtures of low GWP propellants with ethanol [1, 2]. Changes in vapor pressure, density, viscosity, and surface tension can influence the atomization mechanics of pMDI sprays [3–5]. In this study the vapor pressure and viscosity of ethanol with HFA134a, HFA152a, and HFO1234ze(E) were measured with ethanol concentrations varying from 4% w/w to 90% w/w for completeness of the property data.
Original languageEnglish
Title of host publicationProceedings of Respiratory Drug Delivery 2024
PublisherRDD Online
Number of pages5
Publication statusPublished - 2024
EventRespiratory Drug Delivery 2024 - Tuscon, United States of America
Duration: 5 May 20249 May 2024


ConferenceRespiratory Drug Delivery 2024
Abbreviated titleRDD 2023
Country/TerritoryUnited States of America
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