Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions

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Abstract

Melatonin is an endogenous hormone mainly produced by the pineal gland whose dysfunction leads to abnormal sleeping patterns. Changes in melatonin have been reported in acute traumatic brain injury (TBI); however, the impact of environmental conditions typical of the intensive care unit (ICU) has not been assessed. The aim of this study was to compare daily melatonin production in three patient populations treated at the ICU to differentiate the role ofTBI versus ICU conditions. Forty-five patients were recruited and divided into severe TBI, trauma without TBI, medical conditions without trauma, and compared to healthy volunteers. Serum melatonin levels were measured at four daily intervals at 0400 h, 1000 h, 1600 h, and 2200 h for 7 days post-ICU admission by commercial enzyme linked immunosorbent assay. The geometric mean concentrations (95 confidence intervals) of melatonin in these groups showed no difference being 8.3 (6.3?11.0), 9.3 (7.0?12.3), and 8.9 (6.6?11.9) pg/mL, respectively, in TBI, trauma, and intensive care cohorts. All of these patient groups demonstrated decreased melatonin concentrations when compared to control patients.This study suggests thatTBI as well as ICU conditions, may have a role in the dysfunction of melatonin. Monitoring and possibly substituting melatonin acutely in these settings may assist in ameliorating long-term sleep dysfunction in all of these groups, and possibly contribute to reducing secondary brain injury in severe TBI.
Original languageEnglish
Pages (from-to)1 - 7
Number of pages7
JournalFrontiers in Neurology
Volume5
Issue numberArt. No.: 237
DOIs
Publication statusPublished - 2014

Cite this

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title = "Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions",
abstract = "Melatonin is an endogenous hormone mainly produced by the pineal gland whose dysfunction leads to abnormal sleeping patterns. Changes in melatonin have been reported in acute traumatic brain injury (TBI); however, the impact of environmental conditions typical of the intensive care unit (ICU) has not been assessed. The aim of this study was to compare daily melatonin production in three patient populations treated at the ICU to differentiate the role ofTBI versus ICU conditions. Forty-five patients were recruited and divided into severe TBI, trauma without TBI, medical conditions without trauma, and compared to healthy volunteers. Serum melatonin levels were measured at four daily intervals at 0400 h, 1000 h, 1600 h, and 2200 h for 7 days post-ICU admission by commercial enzyme linked immunosorbent assay. The geometric mean concentrations (95 confidence intervals) of melatonin in these groups showed no difference being 8.3 (6.3?11.0), 9.3 (7.0?12.3), and 8.9 (6.6?11.9) pg/mL, respectively, in TBI, trauma, and intensive care cohorts. All of these patient groups demonstrated decreased melatonin concentrations when compared to control patients.This study suggests thatTBI as well as ICU conditions, may have a role in the dysfunction of melatonin. Monitoring and possibly substituting melatonin acutely in these settings may assist in ameliorating long-term sleep dysfunction in all of these groups, and possibly contribute to reducing secondary brain injury in severe TBI.",
author = "Seifman, {Marc Adam} and Keith Gomes and Nguyen, {Phuong N} and Bailey, {Michael John} and Rosenfeld, {Jeffrey Victor} and Cooper, {David James} and Morganti-Kossmann, {Maria Cristina}",
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Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions. / Seifman, Marc Adam; Gomes, Keith; Nguyen, Phuong N; Bailey, Michael John; Rosenfeld, Jeffrey Victor; Cooper, David James; Morganti-Kossmann, Maria Cristina.

In: Frontiers in Neurology, Vol. 5, No. Art. No.: 237, 2014, p. 1 - 7.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions

AU - Seifman, Marc Adam

AU - Gomes, Keith

AU - Nguyen, Phuong N

AU - Bailey, Michael John

AU - Rosenfeld, Jeffrey Victor

AU - Cooper, David James

AU - Morganti-Kossmann, Maria Cristina

PY - 2014

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N2 - Melatonin is an endogenous hormone mainly produced by the pineal gland whose dysfunction leads to abnormal sleeping patterns. Changes in melatonin have been reported in acute traumatic brain injury (TBI); however, the impact of environmental conditions typical of the intensive care unit (ICU) has not been assessed. The aim of this study was to compare daily melatonin production in three patient populations treated at the ICU to differentiate the role ofTBI versus ICU conditions. Forty-five patients were recruited and divided into severe TBI, trauma without TBI, medical conditions without trauma, and compared to healthy volunteers. Serum melatonin levels were measured at four daily intervals at 0400 h, 1000 h, 1600 h, and 2200 h for 7 days post-ICU admission by commercial enzyme linked immunosorbent assay. The geometric mean concentrations (95 confidence intervals) of melatonin in these groups showed no difference being 8.3 (6.3?11.0), 9.3 (7.0?12.3), and 8.9 (6.6?11.9) pg/mL, respectively, in TBI, trauma, and intensive care cohorts. All of these patient groups demonstrated decreased melatonin concentrations when compared to control patients.This study suggests thatTBI as well as ICU conditions, may have a role in the dysfunction of melatonin. Monitoring and possibly substituting melatonin acutely in these settings may assist in ameliorating long-term sleep dysfunction in all of these groups, and possibly contribute to reducing secondary brain injury in severe TBI.

AB - Melatonin is an endogenous hormone mainly produced by the pineal gland whose dysfunction leads to abnormal sleeping patterns. Changes in melatonin have been reported in acute traumatic brain injury (TBI); however, the impact of environmental conditions typical of the intensive care unit (ICU) has not been assessed. The aim of this study was to compare daily melatonin production in three patient populations treated at the ICU to differentiate the role ofTBI versus ICU conditions. Forty-five patients were recruited and divided into severe TBI, trauma without TBI, medical conditions without trauma, and compared to healthy volunteers. Serum melatonin levels were measured at four daily intervals at 0400 h, 1000 h, 1600 h, and 2200 h for 7 days post-ICU admission by commercial enzyme linked immunosorbent assay. The geometric mean concentrations (95 confidence intervals) of melatonin in these groups showed no difference being 8.3 (6.3?11.0), 9.3 (7.0?12.3), and 8.9 (6.6?11.9) pg/mL, respectively, in TBI, trauma, and intensive care cohorts. All of these patient groups demonstrated decreased melatonin concentrations when compared to control patients.This study suggests thatTBI as well as ICU conditions, may have a role in the dysfunction of melatonin. Monitoring and possibly substituting melatonin acutely in these settings may assist in ameliorating long-term sleep dysfunction in all of these groups, and possibly contribute to reducing secondary brain injury in severe TBI.

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