Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: The aim of this study was to determine if measurement of B cell protective immunity was associated with susceptibility to sinopulmonary infection in kidney transplant recipients. Methods and Materials: A prospective cohort of 168 patients with stable graft function (median 4.1 years) underwent assessment of B-lymphocyte antigen CD19 (CD19+) cell number, immunoglobulin G concentration, and seroresponses to influenza vaccination upon study entry. Patients received a single dose of a trivalent, seasonal influenza vaccine. Results: After 2 years follow-up, 31 patients (18%) developed sinopulmonary infection. CD19+ cell number was strongly associated with future sinopulmonary infection. A higher proportion of patients with CD19+ cell counts below the fifth percentile for controls developed sinopulmonary infections than those above the fifth percentile, 30% (23 of 77 patients) compared with 9% (7 of 79 patients; P =.001). There was a trend toward a higher proportion of patients with reduced immunoglobulin G concentrations developing infections than in the normal range for controls, 29% (14 of 48 patients) compared with 15% (16 of 108 patients; P =.060). Influenza vaccination seroresponses were poor in patients and controls such that they could not be used to identify a subgroup of patients at high risk for the development of severe pulmonary infection. Conclusions: Monitoring B-cell numbers represents a simple, inexpensive means of stratifying transplant recipients’ risk of sinopulmonary infection.

Original languageEnglish
Pages (from-to)3367-3370
Number of pages4
JournalTransplantation Proceedings
Volume50
Issue number10
DOIs
Publication statusPublished - 1 Dec 2018

Cite this

@article{4ce4d33f60094e64967c6d36873ce808,
title = "Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients",
abstract = "Purpose: The aim of this study was to determine if measurement of B cell protective immunity was associated with susceptibility to sinopulmonary infection in kidney transplant recipients. Methods and Materials: A prospective cohort of 168 patients with stable graft function (median 4.1 years) underwent assessment of B-lymphocyte antigen CD19 (CD19+) cell number, immunoglobulin G concentration, and seroresponses to influenza vaccination upon study entry. Patients received a single dose of a trivalent, seasonal influenza vaccine. Results: After 2 years follow-up, 31 patients (18{\%}) developed sinopulmonary infection. CD19+ cell number was strongly associated with future sinopulmonary infection. A higher proportion of patients with CD19+ cell counts below the fifth percentile for controls developed sinopulmonary infections than those above the fifth percentile, 30{\%} (23 of 77 patients) compared with 9{\%} (7 of 79 patients; P =.001). There was a trend toward a higher proportion of patients with reduced immunoglobulin G concentrations developing infections than in the normal range for controls, 29{\%} (14 of 48 patients) compared with 15{\%} (16 of 108 patients; P =.060). Influenza vaccination seroresponses were poor in patients and controls such that they could not be used to identify a subgroup of patients at high risk for the development of severe pulmonary infection. Conclusions: Monitoring B-cell numbers represents a simple, inexpensive means of stratifying transplant recipients’ risk of sinopulmonary infection.",
author = "C. Dendle and Stuart, {R. L.} and Mulley, {W. R.} and Polkinghorne, {K. R.} and Gan, {P. Y.} and J. Kanellis and J. Ngui and K. Laurie and K. Thursky and Leung, {V. K.} and Holdsworth, {S. R.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.transproceed.2018.07.017",
language = "English",
volume = "50",
pages = "3367--3370",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier",
number = "10",

}

Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients. / Dendle, C.; Stuart, R. L.; Mulley, W. R.; Polkinghorne, K. R.; Gan, P. Y.; Kanellis, J.; Ngui, J.; Laurie, K.; Thursky, K.; Leung, V. K.; Holdsworth, S. R.

In: Transplantation Proceedings, Vol. 50, No. 10, 01.12.2018, p. 3367-3370.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients

AU - Dendle, C.

AU - Stuart, R. L.

AU - Mulley, W. R.

AU - Polkinghorne, K. R.

AU - Gan, P. Y.

AU - Kanellis, J.

AU - Ngui, J.

AU - Laurie, K.

AU - Thursky, K.

AU - Leung, V. K.

AU - Holdsworth, S. R.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Purpose: The aim of this study was to determine if measurement of B cell protective immunity was associated with susceptibility to sinopulmonary infection in kidney transplant recipients. Methods and Materials: A prospective cohort of 168 patients with stable graft function (median 4.1 years) underwent assessment of B-lymphocyte antigen CD19 (CD19+) cell number, immunoglobulin G concentration, and seroresponses to influenza vaccination upon study entry. Patients received a single dose of a trivalent, seasonal influenza vaccine. Results: After 2 years follow-up, 31 patients (18%) developed sinopulmonary infection. CD19+ cell number was strongly associated with future sinopulmonary infection. A higher proportion of patients with CD19+ cell counts below the fifth percentile for controls developed sinopulmonary infections than those above the fifth percentile, 30% (23 of 77 patients) compared with 9% (7 of 79 patients; P =.001). There was a trend toward a higher proportion of patients with reduced immunoglobulin G concentrations developing infections than in the normal range for controls, 29% (14 of 48 patients) compared with 15% (16 of 108 patients; P =.060). Influenza vaccination seroresponses were poor in patients and controls such that they could not be used to identify a subgroup of patients at high risk for the development of severe pulmonary infection. Conclusions: Monitoring B-cell numbers represents a simple, inexpensive means of stratifying transplant recipients’ risk of sinopulmonary infection.

AB - Purpose: The aim of this study was to determine if measurement of B cell protective immunity was associated with susceptibility to sinopulmonary infection in kidney transplant recipients. Methods and Materials: A prospective cohort of 168 patients with stable graft function (median 4.1 years) underwent assessment of B-lymphocyte antigen CD19 (CD19+) cell number, immunoglobulin G concentration, and seroresponses to influenza vaccination upon study entry. Patients received a single dose of a trivalent, seasonal influenza vaccine. Results: After 2 years follow-up, 31 patients (18%) developed sinopulmonary infection. CD19+ cell number was strongly associated with future sinopulmonary infection. A higher proportion of patients with CD19+ cell counts below the fifth percentile for controls developed sinopulmonary infections than those above the fifth percentile, 30% (23 of 77 patients) compared with 9% (7 of 79 patients; P =.001). There was a trend toward a higher proportion of patients with reduced immunoglobulin G concentrations developing infections than in the normal range for controls, 29% (14 of 48 patients) compared with 15% (16 of 108 patients; P =.060). Influenza vaccination seroresponses were poor in patients and controls such that they could not be used to identify a subgroup of patients at high risk for the development of severe pulmonary infection. Conclusions: Monitoring B-cell numbers represents a simple, inexpensive means of stratifying transplant recipients’ risk of sinopulmonary infection.

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U2 - 10.1016/j.transproceed.2018.07.017

DO - 10.1016/j.transproceed.2018.07.017

M3 - Article

VL - 50

SP - 3367

EP - 3370

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 10

ER -