MEASUREMENT OF CHOROIDAL MELANOMAS: A COMPARISON OF METHODS

IAN FAVILLA, WILLIAM BARRY, JOHN McNEIL, JOHN McKENZIE, ANDREW GOSBELL, PETER ELLIMS

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

The prognosis for death from metastatic choroidal melanoma following enucleation has been shown to be strongly correlated with a number of risk factors of which the most important are age of onset, aggressive cell types and tumour volume. The advantages of enucleation for the treatment of choroidal melanomas are put into question by the singular lack of a parallel increase in life expectancy following this treatment, and evidence that it may promote the development of metastatic disease. Alternative forms of treatment have been introduced including observation of small and asymptomatic tumours. We are using a computer‐aided system for serial measurement and statistical analysis of area and volume of choroidal melanomas. A comparison of results using our method and the conventional method of estimating volume by the product of basal area and height for 51 measurements on 15 eyes over a 6‐month period showed an overestimate of volume by conventional methods which could be corrected by applying a “shape constant” determined by linear regression. Calculation of tumour growth rates is also shape‐dependent, and a slowing in growth rate or even a reduction in melanoma size is possible.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalAustralian and New Zealand Journal of Ophthalmology
Volume16
Issue number2
DOIs
Publication statusPublished - 1 Jan 1988
Externally publishedYes

Keywords

  • area measurement
  • computers
  • ocular melanomas
  • shape constant.
  • volume measurement

Cite this