Projects per year
Abstract
Background: Inbreeding mating has been widely accepted as the key mechanism to enhance homozygosity which normally will decrease the fitness of the population. Although this result has been validated by a large amount of biological data from the natural populations, a mathematical proof of these experimental discoveries is still not complete. A related question is whether we can extend the wellestablished result regarding the mean fitness from a randomly mating population to inbreeding populations. A confirmative answer may provide insights into the frequent occurrence of selffertilization populations.
Results: This work presents a theoretic proof of the result that, for a large inbreeding population with directional relative genotype fitness, the mean fitness of population increases monotonically. However, it cannot be extended to the case with overdominant genotype fitness. In addition, by employing multiplicative intersection hypothesis, we prove that inbreeding mating does decrease the mean fitness of polygenic population in general, but does not decrease the mean fitness with mixed dominantrecessive genotypes. We also prove a novel result that inbreeding depression depends on not only the mating pattern but also genetic structure of population.
Conclusions: For natural inbreeding populations without serious inbreeding depression, our theoretical analysis suggests the majority of its genotypes should be additive or dominantrecessive genotypes. This result gives a reason to explain why many hermaphroditism populations do not show severe inbreeding depression. In addition, the calculated purging rate shows that inbreeding mating purges the deleterious mutants more efficiently than randomly mating does.
Original language  English 

Article number  196 
Number of pages  11 
Journal  BMC Genomics 
Volume  18 
Issue number  Suppl 2 
DOIs  
Publication status  Published  14 Mar 2017 
Projects
 2 Finished

Stochastic Populations: Theory and Applications
Klebaner, F., Barbour, A. P., Hamza, K. & Jagers, P.
Australian Research Council (ARC), University of Melbourne
3/01/12 → 30/09/15
Project: Research

Stochastic modelling of telomere length regulation in ageing research
Australian Research Council (ARC), Monash University
3/01/12 → 30/10/17
Project: Research