@inproceedings{976435ad5e23496d8c47bff5318d85a0,
title = "Mathematical modeling of the influence of RKIP on the ERK signaling pathway",
abstract = "This paper investigates the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simulation. Using nonlinear ordinary differential equations to represent biochemical reactions in the pathway, we suggest a technique for parameter estimation, utilizing time series data of proteins involved in the signaling pathway. The mathematical model allows the simulation the sensitivity of the ERK pathway to variations of initial RKIP and ERK-PP (phosphorylated ERK) concentrations along with time. Throughout the simulation study, we can qualitatively validate the proposed mathematical model compared with experimental results.",
author = "Cho, {Kwang Hyun} and Shin, {Sung Young} and Kim, {Hyun Woo} and Olaf Wolkenhauer and Brian McFerran and Walter Kolch",
year = "2003",
month = jan,
day = "1",
doi = "10.1007/3-540-36481-1_11",
language = "English",
isbn = "3540006052",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer-Verlag London Ltd.",
pages = "127--141",
editor = "Corrado Priami",
booktitle = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
address = "Germany",
note = "1st International Workshop on Computational Methods in Systems Biology, CMSB 2003 ; Conference date: 24-02-2003 Through 26-02-2003",
}