Mathematical modeling of the influence of RKIP on the ERK signaling pathway

Kwang Hyun Cho, Sung Young Shin, Hyun Woo Kim, Olaf Wolkenhauer, Brian McFerran, Walter Kolch

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

80 Citations (Scopus)

Abstract

This paper investigates the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simulation. Using nonlinear ordinary differential equations to represent biochemical reactions in the pathway, we suggest a technique for parameter estimation, utilizing time series data of proteins involved in the signaling pathway. The mathematical model allows the simulation the sensitivity of the ERK pathway to variations of initial RKIP and ERK-PP (phosphorylated ERK) concentrations along with time. Throughout the simulation study, we can qualitatively validate the proposed mathematical model compared with experimental results.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
EditorsCorrado Priami
PublisherSpringer-Verlag London Ltd.
Pages127-141
Number of pages15
ISBN (Print)3540006052, 9783540006053
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes
Event1st International Workshop on Computational Methods in Systems Biology, CMSB 2003 - Rovereto, Italy
Duration: 24 Feb 200326 Feb 2003

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume2602
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Computational Methods in Systems Biology, CMSB 2003
CountryItaly
CityRovereto
Period24/02/0326/02/03

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