TY - JOUR
T1 - Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial
AU - Rodda, Christine P
AU - Benson, Jodie Elise
AU - Vincent, Amanda Jane
AU - Whitehead, Clare Louise
AU - Polyakov, Alex
AU - Vollenhoven, Beverley Janine
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency.
DESIGN: Open-label randomized controlled trial.
SETTING: Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic.
PARTICIPANTS:Seventy-eight women with singleton pregnancies with vitamin D deficiency/insufficiency (serum 25-OH Vit D <75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited.
INTERVENTION:Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation.
MAIN OUTCOME MEASURES:The primary outcome was neonatal serum 25-OH vit D concentration at delivery. The secondary outcome was maternal serum 25-OH vit D concentration at delivery.
RESULTS:Baseline mean maternal serum 25-OH vit D concentrations were similar (P = 0?9) between treatment (32 nmol/l, 95 confidence interval 26-39 nmol/l) and control groups (33 nmol/l, 95 CI 26-39 nmol/l). Umbilical cord serum 25-OH vit D concentrations at delivery were higher (P <0?0001) in neonates of treatment group mothers (81 nmol/l, 95 CI; 70-91 nmol/l) compared with neonates of control group mothers (42 nmol/l, 95 CI; 34-50 nmol/l) with a strongly positive correlation between maternal serum 25-OH Vit D and umbilical cord serum 25-OH vit D concentrations at delivery (Spearman rank correlation coefficient 0?88; P <0?0001). Mean maternal serum 25-OH Vit D concentrations at delivery were higher (P <0?0001) in the treatment group (71 nmol/l, 95 CI; 62-81 nmol/l) compared with the control group (36 nmol/l, 95 CI; 29-42 nmol/l).
CONCLUSION:Vitamin D supplementation of vitamin D deficient pregnant women prevents neonatal vitamin D deficiency.
AB - OBJECTIVE: To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency.
DESIGN: Open-label randomized controlled trial.
SETTING: Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic.
PARTICIPANTS:Seventy-eight women with singleton pregnancies with vitamin D deficiency/insufficiency (serum 25-OH Vit D <75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited.
INTERVENTION:Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation.
MAIN OUTCOME MEASURES:The primary outcome was neonatal serum 25-OH vit D concentration at delivery. The secondary outcome was maternal serum 25-OH vit D concentration at delivery.
RESULTS:Baseline mean maternal serum 25-OH vit D concentrations were similar (P = 0?9) between treatment (32 nmol/l, 95 confidence interval 26-39 nmol/l) and control groups (33 nmol/l, 95 CI 26-39 nmol/l). Umbilical cord serum 25-OH vit D concentrations at delivery were higher (P <0?0001) in neonates of treatment group mothers (81 nmol/l, 95 CI; 70-91 nmol/l) compared with neonates of control group mothers (42 nmol/l, 95 CI; 34-50 nmol/l) with a strongly positive correlation between maternal serum 25-OH Vit D and umbilical cord serum 25-OH vit D concentrations at delivery (Spearman rank correlation coefficient 0?88; P <0?0001). Mean maternal serum 25-OH Vit D concentrations at delivery were higher (P <0?0001) in the treatment group (71 nmol/l, 95 CI; 62-81 nmol/l) compared with the control group (36 nmol/l, 95 CI; 29-42 nmol/l).
CONCLUSION:Vitamin D supplementation of vitamin D deficient pregnant women prevents neonatal vitamin D deficiency.
UR - http://onlinelibrary.wiley.com/doi/10.1111/cen.12762/pdf
U2 - 10.1111/cen.12762
DO - 10.1111/cen.12762
M3 - Article
SN - 0300-0664
VL - 83
SP - 363
EP - 368
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 3
ER -