Maternal serum inhibin-A in pregnancies complicated by insulin dependent diabetes mellitus

Euan M. Wallace, Jennifer A. Crossley, Savitri C. Ritoe, Nigel P. Groome, David A. Aitken

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Abstract

We have examined whether insulin dependant diabetes mellitus (IDDM) affects maternal serum levels of inhibin-A, a recently described prenatal marker of Down's syndrome, by comparing levels in 169 women with IDDM with levels in 432 nondiabetic pregnant women between 15 and 20 weeks of gestation. There was a small but significant increase in the inhibin-A level in the diabetic women only when levels were corrected for maternal weight: median MoM 1.17 (P < 0.01 vs controls, Student’s t test). The underlying mechanism for this elevation in pregnancies complicated by IDDM currently remains obscure.

Original languageEnglish
Pages (from-to)946-948
Number of pages3
JournalBritish Journal of Obstetrics and Gynaecology
Volume104
Issue number8
DOIs
Publication statusPublished - Aug 1997

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