Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring

Mahta Moussavi; Annalisa Cuskelly; Yoonsung Jung; Deborah M. Hodgson; Javad Barouei

doi:10.1093/bbb/zbac199

Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring

Mahta Moussavi
, Annalisa Cuskelly
, Yoonsung Jung
, Deborah M. Hodgson
, Javad Barouei

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Corticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions.

Original language	English
Pages (from-to)	308-313
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	87
Issue number	3
DOIs	https://doi.org/10.1093/bbb/zbac199
Publication status	Published - Mar 2023
Externally published	Yes

Keywords

corticotropin-releasing hormone receptor
Ileum
neonatal maternal separation
probiotic

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10.1093/bbb/zbac199

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title = "Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring",

abstract = "Corticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions.",

keywords = "corticotropin-releasing hormone receptor, Ileum, neonatal maternal separation, probiotic",

author = "Mahta Moussavi and Annalisa Cuskelly and Yoonsung Jung and Hodgson, \{Deborah M.\} and Javad Barouei",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.",

year = "2023",

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doi = "10.1093/bbb/zbac199",

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AU - Moussavi, Mahta

AU - Cuskelly, Annalisa

AU - Jung, Yoonsung

AU - Hodgson, Deborah M.

AU - Barouei, Javad

PY - 2023/3

Y1 - 2023/3

N2 - Corticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions.

AB - Corticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions.

KW - corticotropin-releasing hormone receptor

KW - Ileum

KW - neonatal maternal separation

KW - probiotic

UR - https://www.scopus.com/pages/publications/85148773346

U2 - 10.1093/bbb/zbac199

DO - 10.1093/bbb/zbac199

M3 - Article

C2 - 36477851

AN - SCOPUS:85148773346

SN - 0916-8451

VL - 87

SP - 308

EP - 313

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 3

ER -

Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring

Abstract

Keywords

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