Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

Kirsten R. Palmer, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Laura Tuohey, Manarangi S De Silva, Manuel Varas-Godoy, Stephanie Acuna, Jose Galaz, Stephen Tong, Sebastian E Illanes

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Objective: sFLT-1 e15a is a recently described sFlt-1 variant that is placental and primate specific. As such, it may have potential as a biomarker. Using a newly developed ELISA, we measured maternal plasma sFLT-1 e15a levels in women with fetal growth restriction and pre-eclampsia. Method: We performed a nested case-control study where we measured total sFLT-1 and sFLT-1 e15a plasma protein concentrations. Samples, selected from a prospective cohort study, consisted of 87 healthy controls, 11 cases that developed term preeclampsia and 20 cases where there was fetal growth restriction. We also measured sFLT-1 and sFLT-1 e15a plasma concentrations in a separate cohort: 15 cases of preterm preeclampsia and 24 healthy controls. Results: The prospective case-control cohort demonstrated significantly increased sFLT-1 e15a among cases with term fetal growth restriction (p?
Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalThe Journal of Maternal-Fetal and Neonatal Medicine
Issue number6
Publication statusPublished - 2017

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