TY - JOUR
T1 - Maternal moderate physical training during pregnancy attenuates the effects of a low-protein diet on the impaired secretion of insulin in rats
T2 - Potential role for compensation of insulin resistance and preventing gestational diabetes mellitus
AU - Leandro, Carol Góis
AU - Fidalgo, Marco
AU - Bento-Santos, Adriano
AU - Falcão-Tebas, Filippe
AU - Vasconcelos, Diogo
AU - Manhães-De-Castro, Raul
AU - Carpinelli, Angelo Rafael
AU - Hirabara, Sandro Massao
AU - Curi, Rui
PY - 2012
Y1 - 2012
N2 - The effects of pregestational and gestational low-to-moderate physical training on insulin secretion in undernourished mothers were evaluated. Virgin female Wistar rats were divided into four groups as follows: control (C, n = 5); trained (T, n = 5); low-protein diet (LP, n = 5); trained with a low-protein diet (T + LP, n = 5). Trained rats ran on a treadmill over a period of 4 weeks before mate (5 days week-1 and 60 min day-1, at 65 of VO 2max). At pregnancy, the intensity and duration of the exercise were reduced. Low-protein groups were provided with an 8 casein diet, and controls were provided with a 17 casein diet. At third day after delivery, mothers and pups were killed and islets were isolated by collagenase digestion of pancreas and incubated for a further 1 h with medium containing 5.6 or 16.7 mM glucose. T mothers showed increased insulin secretion by isolated islets incubated with 16.7 mM glucose, whereas LP group showed reduced secretion of insulin by isolated islets when compared with both C and LP + T groups. Physical training before and during pregnancy attenuated the effects of a low-protein diet on the secretion of insulin, suggesting a potential role for compensation of insulin resistance and preventing gestational diabetes mellitus.
AB - The effects of pregestational and gestational low-to-moderate physical training on insulin secretion in undernourished mothers were evaluated. Virgin female Wistar rats were divided into four groups as follows: control (C, n = 5); trained (T, n = 5); low-protein diet (LP, n = 5); trained with a low-protein diet (T + LP, n = 5). Trained rats ran on a treadmill over a period of 4 weeks before mate (5 days week-1 and 60 min day-1, at 65 of VO 2max). At pregnancy, the intensity and duration of the exercise were reduced. Low-protein groups were provided with an 8 casein diet, and controls were provided with a 17 casein diet. At third day after delivery, mothers and pups were killed and islets were isolated by collagenase digestion of pancreas and incubated for a further 1 h with medium containing 5.6 or 16.7 mM glucose. T mothers showed increased insulin secretion by isolated islets incubated with 16.7 mM glucose, whereas LP group showed reduced secretion of insulin by isolated islets when compared with both C and LP + T groups. Physical training before and during pregnancy attenuated the effects of a low-protein diet on the secretion of insulin, suggesting a potential role for compensation of insulin resistance and preventing gestational diabetes mellitus.
UR - http://www.scopus.com/inward/record.url?scp=84866151580&partnerID=8YFLogxK
U2 - 10.1155/2012/805418
DO - 10.1155/2012/805418
M3 - Article
C2 - 22927722
AN - SCOPUS:84866151580
SN - 1110-7243
VL - 2012
JO - Journal of Biomedicine and Biotechnology
JF - Journal of Biomedicine and Biotechnology
M1 - 805418
ER -