TY - JOUR
T1 - Maternal diet quality and associations with plasma lipid profiles and pregnancy-related cardiometabolic health
AU - van der Pligt, Paige F.
AU - Kuswara, Konsita
AU - McNaughton, Sarah A.
AU - Abbott, Gavin
AU - Islam, Sheikh Mohammed Shariful
AU - Huynh, Kevin
AU - Meikle, Peter J.
AU - Mousa, Aya
AU - Ellery, Stacey J.
N1 - Funding Information:
Sources of support (grants and fellowships/funding): This study was funded by the Deakin University Faculty of Health, Health Research Capacity Building Grant Scheme. Initial lipidomic analyses was funded by a Monash Health and Translation Precinct seed grant to Stacey Ellery and Aya Mousa. Stacey Ellery was supported by an Australian NHMRC Early Career Fellowship (1125539). Shariful Islam was funded by a Heart Foundation Postdoctoral Fellowship and NHMRC Emerging Leadership Fellowship. Kevin Huynh and Peter Meikle were supported by a NHMRC Investigator grants (1197190 and 2009965). Aya Mousa is funded by an Australian NHMRC Biomedical Research Fellowship (1161871). This work was supported by the Victorian Government’s Operational Infrastructure Support Program. The authors would like to thank the participants of the CPO study, their pregnancy care providers and their families. We also wish to thank the broader CPO research team for their efforts in sample collection and processing and Monash Health.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Purpose: To assess the relationship of early pregnancy maternal diet quality (DQ) with maternal plasma lipids and indicators of cardiometabolic health, including blood pressure (BP), gestational diabetes mellitus (GDM) and gestational weight gain (GWG). Methods: Women (n = 215) aged 18–40 years with singleton pregnancies were recruited at 10–20 weeks gestation. Diet quality was assessed by the Dietary Guideline Index, calculated at early ([mean ± SD]) (15 ± 3 weeks) and late (35 ± 2 weeks) pregnancy. Lipidomic analysis was performed, and 698 species across 37 lipid classes were measured from plasma blood samples collected at early (15 ± 3 weeks) and mid (27 ± 3 weeks)-pregnancy. Clinical measures (BP, GDM diagnosis, weight) and blood samples were collected across pregnancy. Multiple linear and logistic regression models assessed associations of early pregnancy DQ with plasma lipids at early and mid-pregnancy, BP at three antenatal visits, GDM diagnosis and total GWG. Results: Maternal DQ scores ([mean ± SD]) decreased significantly from early (70.7 ± 11.4) to late pregnancy (66.5 ± 12.6) (p < 0.0005). At a false discovery rate of 0.2, early pregnancy DQ was significantly associated with 13 plasma lipids at mid-pregnancy, including negative associations with six triglycerides (TGs); TG(54:0)[NL-18:0] (neutral loss), TG(50:1)[NL-14:0], TG(48:0)[NL-18:0], TG(52:1)[NL-18:0], TG(54:1)[NL-18:1], TG(50:0)[NL-18:0]. No statistically significant associations were found between early pregnancy DQ and BP, GDM or GWG. Conclusion: Maternal diet did not adhere to Australian Dietary Guidelines. Diet quality was inversely associated with multiple plasma TGs. This study provides novel insights into the relationship between DQ, lipid biomarkers and cardiometabolic health during pregnancy.
AB - Purpose: To assess the relationship of early pregnancy maternal diet quality (DQ) with maternal plasma lipids and indicators of cardiometabolic health, including blood pressure (BP), gestational diabetes mellitus (GDM) and gestational weight gain (GWG). Methods: Women (n = 215) aged 18–40 years with singleton pregnancies were recruited at 10–20 weeks gestation. Diet quality was assessed by the Dietary Guideline Index, calculated at early ([mean ± SD]) (15 ± 3 weeks) and late (35 ± 2 weeks) pregnancy. Lipidomic analysis was performed, and 698 species across 37 lipid classes were measured from plasma blood samples collected at early (15 ± 3 weeks) and mid (27 ± 3 weeks)-pregnancy. Clinical measures (BP, GDM diagnosis, weight) and blood samples were collected across pregnancy. Multiple linear and logistic regression models assessed associations of early pregnancy DQ with plasma lipids at early and mid-pregnancy, BP at three antenatal visits, GDM diagnosis and total GWG. Results: Maternal DQ scores ([mean ± SD]) decreased significantly from early (70.7 ± 11.4) to late pregnancy (66.5 ± 12.6) (p < 0.0005). At a false discovery rate of 0.2, early pregnancy DQ was significantly associated with 13 plasma lipids at mid-pregnancy, including negative associations with six triglycerides (TGs); TG(54:0)[NL-18:0] (neutral loss), TG(50:1)[NL-14:0], TG(48:0)[NL-18:0], TG(52:1)[NL-18:0], TG(54:1)[NL-18:1], TG(50:0)[NL-18:0]. No statistically significant associations were found between early pregnancy DQ and BP, GDM or GWG. Conclusion: Maternal diet did not adhere to Australian Dietary Guidelines. Diet quality was inversely associated with multiple plasma TGs. This study provides novel insights into the relationship between DQ, lipid biomarkers and cardiometabolic health during pregnancy.
KW - Cardiometabolic disease
KW - Cardiovascular disease
KW - Diet quality
KW - Lipidomics
KW - Pregnancy
UR - https://www.scopus.com/pages/publications/85169156895
U2 - 10.1007/s00394-023-03244-3
DO - 10.1007/s00394-023-03244-3
M3 - Article
C2 - 37646831
AN - SCOPUS:85169156895
SN - 1436-6207
VL - 62
SP - 3369
EP - 3381
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 8
ER -
SDG 3 Good Health and Well-being