Mass spectrometry-based proteomic data for cancer diagnosis using interval type-2 fuzzy system

Thanh Nguyen, Saeid Nahavandi, Abbas Khosravi, Douglas Creighton

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

1 Citation (Scopus)

Abstract

An interval type-2 fuzzy logic system is introduced for cancer diagnosis using mass spectrometry-based proteomic data. The fuzzy system is incorporated with a feature extraction procedure that combines wavelet transform and Wilcoxon ranking test. The proposed feature extraction generates feature sets that serve as inputs to the type-2 fuzzy classifier. Uncertainty, noise and outliers that are common in the proteomic data motivate the use of type-2 fuzzy system. Tabu search is applied for structure learning of the fuzzy classifier. Experiments are performed using two benchmark proteomic datasets for the prediction of ovarian and pancreatic cancer. The dominance of the suggested feature extraction as well as type-2 fuzzy classifier against their competing methods is showcased through experimental results. The proposed approach therefore is helpful to clinicians and practitioners as it can be implemented as a medical decision support system in practice.

Original languageEnglish
Title of host publicationFUZZ-IEEE 2015 - IEEE International Conference on Fuzzy Systems
EditorsAdnan Yazici, Nikhil R. Pal, Hisao Ishibuchi, Bulent Tutmez, Chin-Teng Lin, Joao M. C. Sousa, Uzay Kaymak, Trevor Martin
PublisherIEEE, Institute of Electrical and Electronics Engineers
ISBN (Electronic)9781467374286
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventIEEE International Conference on Fuzzy Systems 2015 - Istanbul, Türkiye
Duration: 2 Aug 20155 Aug 2015
https://ieeexplore.ieee.org/xpl/conhome/7329077/proceeding

Conference

ConferenceIEEE International Conference on Fuzzy Systems 2015
Abbreviated titleFUZZ-IEEE 2015
Country/TerritoryTürkiye
CityIstanbul
Period2/08/155/08/15
Internet address

Keywords

  • Cancer diagnosis
  • interval type-2 fuzzy logic system
  • mass spectrometry
  • tabu search
  • wavelet transform
  • Wilcoxon test

Cite this