Maspin is not required for embryonic development or tumour suppression

Sonia S Y Teoh, Jessica L Vieusseux, Monica D Prakash, Susan R Berkowicz, Jennii Luu, Catherina H Bird, Ruby H P Law, Carlos J Rosado, John T Price, James C Whisstock, Phillip I Bird

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic utility of maspin expression. Here to reconcile these findings we made conditional knockout mice. Surprisingly, maspin knockout embryos develop into overtly normal animals. Contrary to original reports, maspin re-expression does not inhibit tumour growth or metastasis in vivo, or influence cell migration, invasion or survival in vitro. Bioinformatic analyses reveal that maspin is not commonly under-expressed in cancer, and that perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression.
Original languageEnglish
Pages (from-to)1 - 9
Number of pages9
JournalNature Communications
Volume5
Issue number(Art. No.: 3164)
DOIs
Publication statusPublished - 2014

Cite this

Teoh, S. S. Y., Vieusseux, J. L., Prakash, M. D., Berkowicz, S. R., Luu, J., Bird, C. H., ... Bird, P. I. (2014). Maspin is not required for embryonic development or tumour suppression. Nature Communications, 5((Art. No.: 3164)), 1 - 9. https://doi.org/10.1038/ncomms4164
Teoh, Sonia S Y ; Vieusseux, Jessica L ; Prakash, Monica D ; Berkowicz, Susan R ; Luu, Jennii ; Bird, Catherina H ; Law, Ruby H P ; Rosado, Carlos J ; Price, John T ; Whisstock, James C ; Bird, Phillip I. / Maspin is not required for embryonic development or tumour suppression. In: Nature Communications. 2014 ; Vol. 5, No. (Art. No.: 3164). pp. 1 - 9.
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abstract = "Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic utility of maspin expression. Here to reconcile these findings we made conditional knockout mice. Surprisingly, maspin knockout embryos develop into overtly normal animals. Contrary to original reports, maspin re-expression does not inhibit tumour growth or metastasis in vivo, or influence cell migration, invasion or survival in vitro. Bioinformatic analyses reveal that maspin is not commonly under-expressed in cancer, and that perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression.",
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Teoh, SSY, Vieusseux, JL, Prakash, MD, Berkowicz, SR, Luu, J, Bird, CH, Law, RHP, Rosado, CJ, Price, JT, Whisstock, JC & Bird, PI 2014, 'Maspin is not required for embryonic development or tumour suppression' Nature Communications, vol. 5, no. (Art. No.: 3164), pp. 1 - 9. https://doi.org/10.1038/ncomms4164

Maspin is not required for embryonic development or tumour suppression. / Teoh, Sonia S Y; Vieusseux, Jessica L; Prakash, Monica D; Berkowicz, Susan R; Luu, Jennii; Bird, Catherina H; Law, Ruby H P; Rosado, Carlos J; Price, John T; Whisstock, James C; Bird, Phillip I.

In: Nature Communications, Vol. 5, No. (Art. No.: 3164), 2014, p. 1 - 9.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Vieusseux, Jessica L

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AU - Whisstock, James C

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AB - Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic utility of maspin expression. Here to reconcile these findings we made conditional knockout mice. Surprisingly, maspin knockout embryos develop into overtly normal animals. Contrary to original reports, maspin re-expression does not inhibit tumour growth or metastasis in vivo, or influence cell migration, invasion or survival in vitro. Bioinformatic analyses reveal that maspin is not commonly under-expressed in cancer, and that perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression.

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Teoh SSY, Vieusseux JL, Prakash MD, Berkowicz SR, Luu J, Bird CH et al. Maspin is not required for embryonic development or tumour suppression. Nature Communications. 2014;5((Art. No.: 3164)):1 - 9. https://doi.org/10.1038/ncomms4164