Masking of central diabetes insipidus and hypogonadotrophic hypogonadism by germ cell tumour in suprasellar - Pineal region

Siti Harnida Md Isa, M. Wong, B. A.K. Khalid

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    A patient with β hCG-secreting germ cell carcinoma of the pineal and suprasellar regions presented with hydrocephalus, Parinaud's syndrome, hypopituitarism and polyuria. Central diabetes insipidus was strongly suspected although the water deprivation test was not diagnostic. The polyuria however, responded to ADH analogue when the hypothyroidism and hypocortisolism were treated. Pubertal development was evident and serum testosterone was normal despite the low FSH/LH, suggesting hCG stimulation of Leydig cells. This case illustrates that a β hCG-germ cell tumour of the suprasellar region causing hypopituitarism can mask the presence of central diabetes insipidus and hypogonadotrophic hypogonadism.

    Original languageEnglish
    Pages (from-to)630-632
    Number of pages3
    JournalMedical Journal of Malaysia
    Issue number5
    Publication statusPublished - Dec 2006


    • Diabetes insipidus
    • Germinoma
    • Hypopituitarism
    • Water deprivation

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