Masking of central diabetes insipidus and hypogonadotrophic hypogonadism by germ cell tumour in suprasellar - Pineal region

Siti Harnida Md Isa, M. Wong, B. A.K. Khalid

Research output: Contribution to journalArticleResearchpeer-review


A patient with β hCG-secreting germ cell carcinoma of the pineal and suprasellar regions presented with hydrocephalus, Parinaud's syndrome, hypopituitarism and polyuria. Central diabetes insipidus was strongly suspected although the water deprivation test was not diagnostic. The polyuria however, responded to ADH analogue when the hypothyroidism and hypocortisolism were treated. Pubertal development was evident and serum testosterone was normal despite the low FSH/LH, suggesting hCG stimulation of Leydig cells. This case illustrates that a β hCG-germ cell tumour of the suprasellar region causing hypopituitarism can mask the presence of central diabetes insipidus and hypogonadotrophic hypogonadism.

Original languageEnglish
Pages (from-to)630-632
Number of pages3
JournalMedical Journal of Malaysia
Issue number5
Publication statusPublished - Dec 2006


  • Diabetes insipidus
  • Germinoma
  • Hypopituitarism
  • Water deprivation

Cite this