Markers of vulnerability to obsessive-compulsive disorder in an ultra-high risk sample of patients who developed psychosis

Leonardo F. Fontenelle, Ashleigh Lin, Christos Pantelis, Stephen J. Wood, Barnaby Nelson, Alison R Yung

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Aims: The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis. Methods: Three hundred and eleven patients at ultra-high risk for psychosis were examined at baseline and after a mean of 7.4years follow-up. Patients who developed psychosis with OCD (PSY+OCD; n=13) and psychosis without OCD (PSY-OCD; n=45) were compared in terms of socio-demographic and clinical features. Results: PSY+OCD patients displayed greater severity of depression before and after conversion to PSY+OCD, and increased rates of depressive disorders before exhibiting PSY+OCD. However, they only displayed greater severity of anxiety and increased rates of non-OCD anxiety disorders after psychosis. Further, PSY+OCD patients were more likely to report a positive family history for anxiety disorders than PSY-OCD. Conclusion: Although depression and a family history of anxiety disorder may act as vulnerability markers for OCD in psychosis, the resulting anxiety may be a correlate or a consequence of PSY+OCD.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalEarly Intervention in Psychiatry
Volume6
Issue number2
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Keywords

  • Co-morbidity
  • Follow-up
  • Obsessive-compulsive disorder
  • Psychosis
  • Schizophrenia

Cite this