@article{52453ac0f411445f88815f94f0c96e46,
title = "Marginal zone B cells acquire dendritic cell functions by trogocytosis",
abstract = "Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, antibody production requires MZ B cells to display pathogen antigens bound to major histocompatibility complex class II (MHC II) molecules to T cells. We describe the trogocytic acquisition of these molecules from conventional dendritic cells (cDCs). Complement component 3 (C3) binds to murine and human MHC II on cDCs. MZ B cells recognize C3 with complement receptor 2 (CR2) and trogocytose the MHC II-C3 complexes, which become exposed on their cell surface. The ubiquitin ligase MARCH1 limits the number of MHC II-C3 complexes displayed on cDCs to prevent their elimination through excessive trogocytosis. Capture of C3 by MHC II thus enables the transfer of cDC-like properties to MZ B cells.",
author = "Patrick Schriek and Ching, {Alan C.} and Moily, {Nagaraj S.} and Jessica Moffat and Lynette Beattie and Steiner, {Thiago M.} and Hosking, {Laine M.} and Thurman, {Joshua M.} and Holers, {V. Michael} and Satoshi Ishido and Lahoud, {Mireille H.} and Irina Caminschi and Heath, {William R.} and Mintern, {Justine D.} and Villadangos, {Jose A.}",
note = "Funding Information: National Health and Medical Research Council of Australia 1058193 (J.A.V.), National Health and Medical Research Council of Australia 1016629 (W.R.H., J.A.V.), National Health and Medical Research Council of Australia 1113293 (W.R.H.), Australian Research Council DP110101383 (J.A.V.), Australian Research Council DP160103134 (J.A.V.), Human Frontier Science Program 0064/2011 (S.I., J.A.V.), National Health Institute R01 DK125823 (J.M.T., V.M.H.), NIH R01DK076690 (J.M.T.), and Australian Research Training Program Scholarship (P.S.). Publisher Copyright: {\textcopyright} 2022 American Association for the Advancement of Science. All rights reserved.",
year = "2022",
month = feb,
day = "11",
doi = "10.1126/science.abf7470",
language = "English",
volume = "375",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science (AAAS)",
number = "6581",
}