Mapping where and when necroptotic cell death occurs in disease

Andre L. Samson; James M. Murphy

doi:10.1038/s41418-024-01318-1

Mapping where and when necroptotic cell death occurs in disease

Andre L. Samson
, James M. Murphy

Drug Discovery Biology

Research output: Contribution to journal › Editorial › Other › peer-review

7 Citations (Scopus)

Abstract

A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.

Original language	English
Pages (from-to)	833–835
Number of pages	3
Journal	Cell Death and Differentiation
Volume	31
Issue number	7
DOIs	https://doi.org/10.1038/s41418-024-01318-1
Publication status	Published - 4 Jun 2024

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41418-024-01318-1Licence: CC BY

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title = "Mapping where and when necroptotic cell death occurs in disease",

abstract = "A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.",

author = "Samson, \{Andre L.\} and Murphy, \{James M.\}",

note = "Funding Information: ALS and JMM\textbackslash{}u2019s work was supported by National Health and Medical Research Council of Australia (grants 1172929 to JMM, 2002965 to ALS, and the Independent Research Institutes Infrastructure Support Scheme 9000719), by the Kenneth Rainin Foundation (award to JMM and ALS), and by the Victorian State Government Operational Infrastructure Support scheme. JMM received research funding from Anaxis Pharma Pty Ltd. Publisher Copyright: {\textcopyright} The Author(s) 2024.",

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doi = "10.1038/s41418-024-01318-1",

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AU - Samson, Andre L.

AU - Murphy, James M.

N1 - Funding Information: ALS and JMM\u2019s work was supported by National Health and Medical Research Council of Australia (grants 1172929 to JMM, 2002965 to ALS, and the Independent Research Institutes Infrastructure Support Scheme 9000719), by the Kenneth Rainin Foundation (award to JMM and ALS), and by the Victorian State Government Operational Infrastructure Support scheme. JMM received research funding from Anaxis Pharma Pty Ltd. Publisher Copyright: © The Author(s) 2024.

PY - 2024/6/4

Y1 - 2024/6/4

N2 - A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.

AB - A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.

UR - https://www.scopus.com/pages/publications/85195185838

U2 - 10.1038/s41418-024-01318-1

DO - 10.1038/s41418-024-01318-1

M3 - Editorial

AN - SCOPUS:85195185838

SN - 1350-9047

VL - 31

SP - 833

EP - 835

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 7

ER -

Mapping where and when necroptotic cell death occurs in disease

Abstract

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