Mapping supramedullary pathways involved in cough using functional brain imaging: Comparison with pain

Stuart B. Mazzone, Alice E McGovern, Kendrick Koo, Michael J. Farrell

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)


Several indications suggest that supramedullary brain regions receive sensory information from the airways and provide motor control to the brainstem neurons that control coughing. However, the organization of this circuitry has not been described in any detail. In this short review we will discuss how state-of-the-art functional brain imaging techniques in humans and animals will enable unprecedented insights into the supramedullary brain regions that help control coughing. In addition we will describe the likely similarities between cough-related higher brain networks and those involved in the processing of other aversive sensory modalities, such as pain.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalPulmonary Pharmacology and Therapeutics
Issue number2
Publication statusPublished - Apr 2009
Externally publishedYes


  • Capsaicin
  • Cough suppression
  • fMRI
  • Manganese enhanced MRI
  • Urge-to-cough
  • Voluntary cough

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