Mapping of ApoE4 related white matter damage using diffusion MRI

Sinchai Tsao; Niharika Gajawelli; Darryl H. Hwang; Stephen Kriger; Meng Law; Helena Chui; Michael Weiner; Natasha Lepore

doi:10.1117/12.2043925

Mapping of ApoE4 related white matter damage using diffusion MRI

Sinchai Tsao
, Niharika Gajawelli
, Darryl H. Hwang
, Stephen Kriger
, Meng Law
, Helena Chui
, Michael Weiner
, Natasha Lepore

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

4 Citations (Scopus)

Abstract

ApoliopoproteinE 4 (ApoE-4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE 4 allele. We found potentially significant regions (P_uncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).

Original language	English
Title of host publication	Medical Imaging 2014 - PACS and Imaging Informatics
Subtitle of host publication	Next Generation and Innovations
Editors	Maria Y. Law , Tessa S. Cook
Place of Publication	USA
Publisher	SPIE - International Society for Optical Engineering
Number of pages	5
Volume	9039
ISBN (Print)	9780819498328
DOIs	https://doi.org/10.1117/12.2043925
Publication status	Published - 1 Jan 2014
Externally published	Yes
Event	Conference on Medical Imaging - PACS and Imaging Informatics 2014: Next Generation and Innovations - San Diego, United States of America Duration: 18 Feb 2014 → 20 Feb 2014 http://spie.org/Publications/Proceedings/Volume/9039 (Link to the SPIE proceedings)

Conference

Conference	Conference on Medical Imaging - PACS and Imaging Informatics 2014
Country/Territory	United States of America
City	San Diego
Period	18/02/14 → 20/02/14
Internet address	http://spie.org/Publications/Proceedings/Volume/9039 (Link to the SPIE proceedings)

Keywords

Alzheimer's Disease
ApoE
Dementia
Diusion MRI
DTI
MRI
Neuroimaging

Access to Document

10.1117/12.2043925

Cite this

Tsao, S., Gajawelli, N., Hwang, D. H., Kriger, S., Law, M., Chui, H., Weiner, M., & Lepore, N. (2014). Mapping of ApoE4 related white matter damage using diffusion MRI. In M. Y. Law , & T. S. Cook (Eds.), Medical Imaging 2014 - PACS and Imaging Informatics: Next Generation and Innovations (Vol. 9039). Article 90390H SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2043925

@inproceedings{de03f27fc41b49b3b3da1fd2f1ab3a10,

title = "Mapping of ApoE4 related white matter damage using diffusion MRI",

abstract = "ApoliopoproteinE 4 (ApoE-4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE 4 allele. We found potentially significant regions (Puncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).",

keywords = "Alzheimer's Disease, ApoE, Dementia, Diusion MRI, DTI, MRI, Neuroimaging",

author = "Sinchai Tsao and Niharika Gajawelli and Hwang, \{Darryl H.\} and Stephen Kriger and Meng Law and Helena Chui and Michael Weiner and Natasha Lepore",

year = "2014",

month = jan,

day = "1",

doi = "10.1117/12.2043925",

language = "English",

isbn = "9780819498328",

volume = "9039",

editor = "\{Law \}, \{Maria Y. \} and \{Cook \}, \{Tessa S. \}",

booktitle = "Medical Imaging 2014 - PACS and Imaging Informatics",

publisher = "SPIE - International Society for Optical Engineering",

address = "United States of America",

note = "Conference on Medical Imaging - PACS and Imaging Informatics 2014 : Next Generation and Innovations ; Conference date: 18-02-2014 Through 20-02-2014",

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}

Tsao, S, Gajawelli, N, Hwang, DH, Kriger, S, Law, M, Chui, H, Weiner, M & Lepore, N 2014, Mapping of ApoE4 related white matter damage using diffusion MRI. in MY Law & TS Cook (eds), Medical Imaging 2014 - PACS and Imaging Informatics: Next Generation and Innovations. vol. 9039, 90390H, SPIE - International Society for Optical Engineering, USA, Conference on Medical Imaging - PACS and Imaging Informatics 2014, San Diego, California, United States of America, 18/02/14. https://doi.org/10.1117/12.2043925

Mapping of ApoE4 related white matter damage using diffusion MRI. / Tsao, Sinchai; Gajawelli, Niharika; Hwang, Darryl H. et al.
Medical Imaging 2014 - PACS and Imaging Informatics: Next Generation and Innovations. ed. / Maria Y. Law ; Tessa S. Cook . Vol. 9039 USA: SPIE - International Society for Optical Engineering, 2014. 90390H.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Mapping of ApoE4 related white matter damage using diffusion MRI

AU - Tsao, Sinchai

AU - Gajawelli, Niharika

AU - Hwang, Darryl H.

AU - Kriger, Stephen

AU - Law, Meng

AU - Chui, Helena

AU - Weiner, Michael

AU - Lepore, Natasha

PY - 2014/1/1

Y1 - 2014/1/1

N2 - ApoliopoproteinE 4 (ApoE-4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE 4 allele. We found potentially significant regions (Puncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).

AB - ApoliopoproteinE 4 (ApoE-4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE 4 allele. We found potentially significant regions (Puncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).

KW - Alzheimer's Disease

KW - ApoE

KW - Dementia

KW - Diusion MRI

KW - DTI

KW - MRI

KW - Neuroimaging

UR - https://www.scopus.com/pages/publications/84901783404

U2 - 10.1117/12.2043925

DO - 10.1117/12.2043925

M3 - Conference Paper

AN - SCOPUS:84901783404

SN - 9780819498328

VL - 9039

BT - Medical Imaging 2014 - PACS and Imaging Informatics

A2 - Law , Maria Y.

A2 - Cook , Tessa S.

PB - SPIE - International Society for Optical Engineering

CY - USA

T2 - Conference on Medical Imaging - PACS and Imaging Informatics 2014

Y2 - 18 February 2014 through 20 February 2014

ER -

Mapping of ApoE4 related white matter damage using diffusion MRI

Abstract

Conference

Keywords

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