Mapping of ApoE4 related white matter damage using diffusion MRI

Sinchai Tsao, Niharika Gajawelli, Darryl H. Hwang, Stephen Kriger, Meng Law, Helena Chui, Michael Weiner, Natasha Lepore

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

4 Citations (Scopus)

Abstract

ApoliopoproteinE 4 (ApoE-4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE 4 allele. We found potentially significant regions (Puncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).

Original languageEnglish
Title of host publicationMedical Imaging 2014 - PACS and Imaging Informatics
Subtitle of host publicationNext Generation and Innovations
EditorsMaria Y. Law , Tessa S. Cook
Place of PublicationUSA
PublisherSPIE - International Society for Optical Engineering
Number of pages5
Volume9039
ISBN (Print)9780819498328
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes
EventMedical Imaging 2014 - PACS and Imaging Informatics: Next Generation and Innovations - San Diego, United States of America
Duration: 18 Feb 201420 Feb 2014
http://spie.org/Publications/Proceedings/Volume/9039 (Link to the SPIE proceedings)

Conference

ConferenceMedical Imaging 2014 - PACS and Imaging Informatics
CountryUnited States of America
CitySan Diego
Period18/02/1420/02/14
Internet address

Keywords

  • Alzheimer's Disease
  • ApoE
  • Dementia
  • Diusion MRI
  • DTI
  • MRI
  • Neuroimaging

Cite this

Tsao, S., Gajawelli, N., Hwang, D. H., Kriger, S., Law, M., Chui, H., Weiner, M., & Lepore, N. (2014). Mapping of ApoE4 related white matter damage using diffusion MRI. In M. Y. Law , & T. S. Cook (Eds.), Medical Imaging 2014 - PACS and Imaging Informatics: Next Generation and Innovations (Vol. 9039). [90390H] SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2043925