Abstract
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
Original language | English |
---|---|
Pages (from-to) | E5154-E5163 |
Number of pages | 10 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 115 |
Issue number | 22 |
DOIs | |
Publication status | Published - 29 May 2018 |
Keywords
- Brain asymmetry
- Cortical thickness
- Lateralization
- Meta-analysis
- Surface area
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In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 22, 29.05.2018, p. E5154-E5163.
Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium
AU - Kong, Xiang Zhen
AU - Mathias, Samuel R.
AU - Guadalupe, Tulio
AU - Abé, Christoph
AU - Agartz, Ingrid
AU - Akudjedu, Theophilus N.
AU - Aleman, Andre
AU - Alhusaini, Saud
AU - Allen, Nicholas B.
AU - Ames, David
AU - Andreassen, Ole A.
AU - Vasquez, Alejandro Arias
AU - Armstrong, Nicola J.
AU - Bergo, Felipe
AU - Bastin, Mark E.
AU - Batalla, Albert
AU - Bauer, Jochen
AU - Baune, Bernhard T.
AU - Baur-Streubel, Ramona
AU - Biederman, Joseph
AU - Blaine, Sara K.
AU - Boedhoe, Premika
AU - Bøen, Erlend
AU - Bose, Anushree
AU - Bralten, Janita
AU - Brandeis, Daniel
AU - Brem, Silvia
AU - Brodaty, Henry
AU - Yüksel, Dilara
AU - Brooks, Samantha J.
AU - Buitelaar, Jan
AU - Bürger, Christian
AU - Bülow, Robin
AU - Calhoun, Vince
AU - Calvo, Anna
AU - Canales-Rodríguez, Erick Jorge
AU - Canive, Jose M.
AU - Cannon, Dara M.
AU - Caparelli, Elisabeth C.
AU - Castellanos, Francisco X.
AU - Cavalleri, Gianpiero L.
AU - Cendes, Fernando
AU - Chaim-Avancini, Tiffany Moukbel
AU - Chantiluke, Kaylita
AU - Chen, Qun Lin
AU - Chen, Xiayu
AU - Cheng, Yuqi
AU - Christakou, Anastasia
AU - Clark, Vincent P.
AU - Coghill, David
AU - Connolly, Colm G.
AU - Conzelmann, Annette
AU - Córdova-Palomera, Aldo
AU - Cousijn, Janna
AU - Crow, Tim
AU - Cubillo, Ana
AU - Dale, Anders
AU - Dannlowski, Udo
AU - De Bruttopilo, Sara Ambrosino
AU - De Zeeuw, Patrick
AU - Deary, Ian J.
AU - Delanty, Norman
AU - Demeter, Damion V.
AU - Di Martino, Adriana
AU - Dickie, Erin W.
AU - Dietsche, Bruno
AU - Doan, N. Trung
AU - Doherty, Colin P.
AU - Doyle, Alysa
AU - Durston, Sarah
AU - Earl, Eric
AU - Ehrlich, Stefan
AU - Ekman, Carl Johan
AU - Elvsåshagen, Torbjørn
AU - Epstein, Jeffery N.
AU - Fair, Damien A.
AU - Faraone, Stephen V.
AU - Fernández, Guillén
AU - Filho, Geraldo Busatto
AU - Förster, Katharina
AU - Fouche, Jean Paul
AU - Foxe, John J.
AU - Frodl, Thomas
AU - Fuentes-Claramonte, Paola
AU - Fullerton, Janice
AU - Garavan, Hugh
AU - Garcia, Danielle Do Santos
AU - Gotlib, Ian H.
AU - Goudriaan, Anna E.
AU - Grabe, Hans Jörgen
AU - Groenewold, Nynke A.
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Gurholt, Tiril
AU - Haavik, Jan
AU - Hahn, Tim
AU - Hansell, Narelle K.
AU - Harris, Mathew A.
AU - Hartman, Catharina A.
AU - Hernández, Maria Del Carmen Valdés
AU - Heslenfeld, Dirk
AU - Hester, Robert
AU - Hibar, Derrek Paul
AU - Ho, Beng Choon
AU - Ho, Tiffany C.
AU - Hoekstra, Pieter J.
AU - Van Holst, Ruth J.
AU - Hoogman, Martine
AU - Høvik, Marie F.
AU - Howells, Fleur M.
AU - Hugdahl, Kenneth
AU - Huyser, Chaim
AU - Ingvar, Martin
AU - Irwin, Lourdes
AU - Ishikawa, Akari
AU - James, Anthony
AU - Jahanshad, Neda
AU - Jernigan, Terry L.
AU - Jönsson, Erik G.
AU - Kähler, Claas
AU - Kaleda, Vasily
AU - Kelly, Clare
AU - Kerich, Michael
AU - Keshavan, Matcheri S.
AU - Khadka, Sabin
AU - Kircher, Tilo
AU - Kohls, Gregor
AU - Konrad, Kerstin
AU - Korucuoglu, Ozlem
AU - Krämer, Bernd
AU - Krug, Axel
AU - Kwon, Jun Soo
AU - Lambregts-Rommelse, Nanda
AU - Landén, Mikael
AU - Lázaro, Luisa
AU - Lebedeva, Irina
AU - Lenroot, Rhoshel
AU - Lesch, Klaus Peter
AU - Li, Qinqin
AU - Lim, Kelvin O.
AU - Liu, Jia
AU - Lochner, Christine
AU - London, Edythe D.
AU - Lonning, Vera
AU - Lorenzetti, Valentina
AU - Luciano, Michelle
AU - Luijten, Maartje
AU - Lundervold, Astri J.
AU - MacKey, Scott
AU - MacMaster, Frank P.
AU - Maingault, Sophie
AU - Malpas, Charles B.
AU - Malt, Ulrik F.
AU - Mataix-Cols, David
AU - Martin-Santos, Rocio
AU - Mayer, Andrew R.
AU - McCarthy, Hazel
AU - Mitchell, Philip B.
AU - Mueller, Bryon A.
AU - Maniega, Susana Muñoz
AU - Mazoyer, Bernard
AU - McDonald, Colm
AU - McLellan, Quinn
AU - McMahon, Katie L.
AU - McPhilemy, Genevieve
AU - Momenan, Reza
AU - Morales, Angelica M.
AU - Narayanaswamy, Janardhanan C.
AU - Moreira, José Carlos Vasques
AU - Nerland, Stener
AU - Nestor, Liam
AU - Newman, Erik
AU - Nigg, Joel T.
AU - Nordvik, Jan Egil
AU - Novotny, Stephanie
AU - Weiss, Eileen Oberwelland
AU - O'Gorman, Ruth L.
AU - Oosterlaan, Jaap
AU - Oranje, Bob
AU - Orr, Catherine
AU - Overs, Bronwyn
AU - Pauli, Paul
AU - Paulus, Martin
AU - Plessen, Kerstin Jessica
AU - Von Polier, Georg G.
AU - Pomarol-Clotet, Edith
AU - Portella, Maria J.
AU - Qiu, Jiang
AU - Radua, Joaquim
AU - Ramos-Quiroga, Josep Antoni
AU - Reddy, Y. C.Janardhan
AU - Reif, Andreas
AU - Roberts, Gloria
AU - Rosa, Pedro
AU - Rubia, Katya
AU - Sacchet, Matthew D.
AU - Sachdev, Perminder S.
AU - Salvador, Raymond
AU - Schmaal, Lianne
AU - Schulte-Rüther, Martin
AU - Schweren, Lizanne
AU - Seidman, Larry
AU - Seitz, Jochen
AU - Serpa, Mauricio Henriques
AU - Shaw, Philip
AU - Shumskaya, Elena
AU - Silk, Timothy J.
AU - Simmons, Alan N.
AU - Simulionyte, Egle
AU - Sinha, Rajita
AU - Sjoerds, Zsuzsika
AU - Smelror, Runar Elle
AU - Soliva, Joan Carlos
AU - Solowij, Nadia
AU - Souza-Duran, Fabio Luisde
AU - Sponheim, Scott R.
AU - Stein, Dan J.
AU - Stein, Elliot A.
AU - Stevens, Michael
AU - Strike, Lachlan T.
AU - Sudre, Gustavo
AU - Sui, Jing
AU - Tamm, Leanne
AU - Temmingh, Hendrik S.
AU - Thoma, Robert J.
AU - Tomyshev, Alexander
AU - Tronchin, Giulia
AU - Turner, Jessica
AU - Uhlmann, Anne
AU - Van Erp, Theo G.M.
AU - Van Den Heuvel, Odile A.
AU - Van Der Meer, Dennis
AU - Van Eijk, Liza
AU - Vance, Alasdair
AU - Veer, Ilya M.
AU - Veltman, Dick J.
AU - Venkatasubramanian, Ganesan
AU - Vilarroya, Oscar
AU - Vives-Gilabert, Yolanda
AU - Voineskos, Aristotle N.
AU - Völzke, Henry
AU - Vuletic, Daniella
AU - Walitza, Susanne
AU - Walter, Henrik
AU - Walton, Esther
AU - Wardlaw, Joanna M.
AU - Wen, Wei
AU - Westlye, Lars T.
AU - Whelan, Christopher D.
AU - Yücel, Murat
AU - ENIGMA Laterality Working Group
AU - Glahn, David C.
AU - Franke, Barbara
AU - Crivello, Fabrice
AU - Tzourio-Mazoyer, Nathalie
AU - Fisher, Simon E.
AU - Thompson, Paul M.
AU - Francks, Clyde
N1 - Publisher Copyright: © 2018 National Academy of Sciences. All rights reserved.
PY - 2018/5/29
Y1 - 2018/5/29
N2 - Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
AB - Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
KW - Brain asymmetry
KW - Cortical thickness
KW - Lateralization
KW - Meta-analysis
KW - Surface area
UR - http://www.scopus.com/inward/record.url?scp=85047904406&partnerID=8YFLogxK
U2 - 10.1073/pnas.1718418115
DO - 10.1073/pnas.1718418115
M3 - Article
C2 - 29764998
AN - SCOPUS:85047904406
SN - 0027-8424
VL - 115
SP - E5154-E5163
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 22
ER -