Mapping and sequencing of the murine 'tissue' Transglutaminase (Tgm2) gene: Absence of mutations in MRLlpr/lpr mice [1]

M. D'Amato, C. Iannicola, G. Monteriu, M. Piacentini

Research output: Contribution to journalLetterOtherpeer-review

3 Citations (Scopus)

Abstract

The transglutaminase family includes both intracellular and extracellular enzymes catalyzing Ca2+-dependent reactions which result in the post-translational modification of proteins at the level of glutamine and lysine. This post-translational modification leads to the formation of the e(g-glutamyl)lysine cross-links and/or to the covalent incorporation of polyamines into proteins. The formation of these covalent cross-links leads to the polymerization of substrate points which become very resistant to physical-chemical stress.
Original languageEnglish
Pages (from-to)216-217
Number of pages2
JournalCell Death and Differentiation
Volume6
Issue number3
DOIs
Publication statusPublished - 1 Jan 1999
Externally publishedYes

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