MAOA-uVNTR polymorphism in a Brazilian sample: Further support for the association with impulsive behaviors and alcohol dependence

Verônica Contini, Francine Z C Marques, Carlos E D Garcia, Mara H. Hutz, Claiton H D Bau

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Abstract

The enzyme monoamine oxidase A (MAO A) plays an important role in the metabolism of neurotransmitters. The MAOA gene presents several polymorphisms, including a 30-bp VNTR in the promoter region (MAOA-uVNTR). Alleles with 3.5 and 4 repeats are 2-10 times more efficient than the 3-repeat allele. Several studies have shown an association between the 3-repeat allele and a cluster of externalizing behaviors including alcoholism, antisocial personality, and impulsivity. The objective of the present study is to replicate in a different culture the associations between the MAOA-uVNTR with alcoholism and other phenotypes. The sample comprises 125 Brazilian alcoholics of European descent and 235 controls. The results suggest that the 3-repeat allele is associated to: (1) alcohol dependence (P < 0.05); (2) an earlier onset of alcoholism (P < 0.01); (3) comorbid drug abuse among alcoholics (P < 0.05); and (4) a higher number of antisocial symptoms (P < 0.02). Our results confirmed previous reports showing an association of the low activity 3-repeat allele of MAOA-uVNTR polymorphism with substance dependence and impulsive/antisocial behaviors. These findings in a different culture further support the influence of the MAOA-uVNTR in psychiatric disorders.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume141 B
Issue number3
DOIs
Publication statusPublished - 5 Apr 2006
Externally publishedYes

Keywords

  • Alcoholism
  • Antisocial symptoms
  • Drug abuse
  • Interaction
  • Monoamine oxidase A

Cite this