Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection

William Mulley, John Kanellis, Shaun Andrew Summers

Research output: Contribution to journalArticleOther

6 Citations (Scopus)

Abstract

Management of mental health issues in the post-transplant setting can be difficult given the potential for medication related neurotoxicity. The lack of established guidelines in this area further compounds this difficulty. The current report details the course of patient with stable bipolar affective disorder prior to renal transplantation, who developed de novo psychosis post-transplantation as an adverse effect of her tacrolimus therapy. The patient was unable to take her usual oral immunosuppressants due to the severity of her psychosis and she eventually required alemtuzumab parenterally as rescue therapy from rejection. This case highlights the diagnostic and therapeutic challenges when dealing with transplant recipients with significant psychosis.
Original languageEnglish
Pages (from-to)2 - 5
Number of pages4
JournalNephrology
Volume20 supp 1
DOIs
Publication statusPublished - 2015

Cite this

@article{863f92c0d5694bba8682649dcb3f7384,
title = "Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection",
abstract = "Management of mental health issues in the post-transplant setting can be difficult given the potential for medication related neurotoxicity. The lack of established guidelines in this area further compounds this difficulty. The current report details the course of patient with stable bipolar affective disorder prior to renal transplantation, who developed de novo psychosis post-transplantation as an adverse effect of her tacrolimus therapy. The patient was unable to take her usual oral immunosuppressants due to the severity of her psychosis and she eventually required alemtuzumab parenterally as rescue therapy from rejection. This case highlights the diagnostic and therapeutic challenges when dealing with transplant recipients with significant psychosis.",
author = "William Mulley and John Kanellis and Summers, {Shaun Andrew}",
year = "2015",
doi = "10.1111/nep.12419",
language = "English",
volume = "20 supp 1",
pages = "2 -- 5",
journal = "Nephrology",
issn = "1320-5358",
publisher = "Wiley-Blackwell",

}

Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection. / Mulley, William; Kanellis, John; Summers, Shaun Andrew.

In: Nephrology, Vol. 20 supp 1, 2015, p. 2 - 5.

Research output: Contribution to journalArticleOther

TY - JOUR

T1 - Managing psychosis in a renal transplant recipient with bipolar affective disorder and allograft rejection

AU - Mulley, William

AU - Kanellis, John

AU - Summers, Shaun Andrew

PY - 2015

Y1 - 2015

N2 - Management of mental health issues in the post-transplant setting can be difficult given the potential for medication related neurotoxicity. The lack of established guidelines in this area further compounds this difficulty. The current report details the course of patient with stable bipolar affective disorder prior to renal transplantation, who developed de novo psychosis post-transplantation as an adverse effect of her tacrolimus therapy. The patient was unable to take her usual oral immunosuppressants due to the severity of her psychosis and she eventually required alemtuzumab parenterally as rescue therapy from rejection. This case highlights the diagnostic and therapeutic challenges when dealing with transplant recipients with significant psychosis.

AB - Management of mental health issues in the post-transplant setting can be difficult given the potential for medication related neurotoxicity. The lack of established guidelines in this area further compounds this difficulty. The current report details the course of patient with stable bipolar affective disorder prior to renal transplantation, who developed de novo psychosis post-transplantation as an adverse effect of her tacrolimus therapy. The patient was unable to take her usual oral immunosuppressants due to the severity of her psychosis and she eventually required alemtuzumab parenterally as rescue therapy from rejection. This case highlights the diagnostic and therapeutic challenges when dealing with transplant recipients with significant psychosis.

UR - http://onlinelibrary.wiley.com/doi/10.1111/nep.12419/epdf

U2 - 10.1111/nep.12419

DO - 10.1111/nep.12419

M3 - Article

VL - 20 supp 1

SP - 2

EP - 5

JO - Nephrology

JF - Nephrology

SN - 1320-5358

ER -