Managing patient-specific mechanical ventilation: clinical utilisation of respiratory elastance (CURE) - Model and software development

Daniel P. Redmond, Shaun M. Davidson, Hamish A. Laing, Richard H. White, Faizi Radzi, Yeong Shiong Chiew, Sarah F. Poole, Nor Salwa Damanhuri, Thomas Desaive, Geoffrey M. Shaw, J. Geoffrey Chase

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

1 Citation (Scopus)


Mechanical ventilation (MV) is one of the most common, but difficult, costly and variably delivered therapies in intensive care. Model-based estimated patient-specific respiratory elastance can be used to guide clinical staff in selecting positive end-expiratory pressure (PEEP) for MV patients. The Clinical Utilisation of Respiratory Elastance (CURE) trial investigates the potential to optimise PEEP in MV patients. A software system, CURE Soft, capable of providing real-time patient-specific respiratory elastance was developed for the purpose of CURE clinical trial. CURE Soft uses airway pressure and flow data from the ventilator to calculate respiratory elastance using a time-varying elastance model. The CURE Soft graphical user interface (GUI) was developed to provide patient-specific respiratory elastance in real time, history and response during a recruitment manoeuvre both of which offer significant clinical insight. CURE Soft was extensively tested on a mechanical test lung to verify the model-based elastance estimation and its robustness. Model fitting errors are low across a range of ventilation modes, showing it can successfully identify respiratory elastance. Real-time monitoring of respiratory elastance enables new insights into patient-specific lung condition, with no added patient burden. The additional insight available to clinicians will provide the information necessary for improved decision-making and patient outcomes.

Original languageEnglish
Title of host publication19th IFAC World Congress IFAC 2014, Proceedings
EditorsEdward Boje, Xiaohua Xia
PublisherElsevier - International Federation of Automatic Control (IFAC)
Number of pages6
ISBN (Electronic)9783902823625
Publication statusPublished - 2014
Externally publishedYes
EventInternational Federation of Automatic Control World Congress 2014 - Cape Town International Convention Centre, Cape Town, South Africa
Duration: 24 Aug 201429 Aug 2014
Conference number: 19th

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
ISSN (Print)1474-6670


ConferenceInternational Federation of Automatic Control World Congress 2014
Abbreviated titleIFAC 2014
Country/TerritorySouth Africa
CityCape Town
Internet address

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