Managing HBV in pregnancy. Prevention, prophylaxis, treatment and follow-up: Position paper produced by Australian, UK and New Zealand key opinion leaders

Kumar Visvanathan, Geoff Dusheiko, Michelle Giles, May-Ling Wong, Nghi Phung, Susan Walker, Suong Le, Seng Gee Lim, Ed Gane, Meng Ngu, Winita Hardikar, Ben Cowie, Scott Bowden, Simone Strasser, Miriam Levy, Joe Sasaduesz

Research output: Contribution to journalArticleOtherpeer-review

39 Citations (Scopus)

Abstract

Hepatitis B during pregnancy presents unique management issues for both the mother and fetus. These include the lack of a current cohesive strategy for treatment and follow-up of mothers and their babies; the uncertain risk of postpartum HBV flares; the lack of randomised trial data on the safety and efficacy of antiviral treatment in pregnancy; the lack of head-tohead studies comparing different antivirals in pregnancy; and the lack of epidemiologic information regarding infection across different populations globally. This position paper provides a comprehensive review of the management of women with HBV infection prior to conception, throughout each stage of pregnancy and postpartum, as well as recommendations and clinical approaches for the follow-up of children born to infected mothers, based on available evidence in the literature and recommendations from international experts. Prevention of perinatal transmission is an important component of global efforts to reduce the burden of chronic HBV since vertical transmission is responsible for most of the chronic infection worldwide.

Original languageEnglish
Pages (from-to)340-350
Number of pages11
JournalGut
Volume65
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016
Externally publishedYes

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