Management of Early Node-Positive Breast Cancer in Australia

A Multicentre Study

Emma Gannan, Jeremy Khoo, Sophie S Nightingale, Thomas Surya Suhardja, Jocelyn Lippey, Holly Keane, Kian Jin Tan, David Clouston, Alexandra Gorelik, Gregory Bruce Mann, Jane Fox, The Melbourne Breast Group, David Speakman

Research output: Contribution to journalArticleResearchpeer-review

Abstract

To examine practice patterns for breast cancer patients with limited sentinel node (SN) disease in light of the ACOSOG Z0011 results. Retrospective analysis of patients with T1-2 breast cancer and positive sentinel lymph node biopsy (SLNB) admitted between January 2009 and December 2012. Patient demographics, tumor characteristics, and treatments were recorded. Eight hundred positive SLNBs were identified. A total of 452 (56.5%) proceeded to completion axillary lymph node dissection (cALND). cALND rate decreased from 65.1% to 49.7% from 2009–2010 to 2011–2012. cALND was performed for micrometastasis or isolated tumor cells in 39.3% in 2009–2010 and 22.2% in 2011–2012, whereas for macrometastases the rates were 83.1% and 68.6%, respectively. cALND rates diminished for both Z0011-eligible and -ineligible patients. The ACOSOG Z0011 trial presentation and publication coincided with a reduction in cALND for breast cancer with limited nodal disease. There appears equipoise regarding management of macrometastatic SN disease.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalThe Breast Journal
Volume22
Issue number4
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • ACOSOG Z0011 trial
  • axillary lymph node dissection
  • breast cancer
  • sentinel lymph node biopsy

Cite this

Gannan, E., Khoo, J., Nightingale, S. S., Suhardja, T. S., Lippey, J., Keane, H., ... Speakman, D. (2016). Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study. The Breast Journal, 22(4), 413-419. https://doi.org/10.1111/tbj.12595
Gannan, Emma ; Khoo, Jeremy ; Nightingale, Sophie S ; Suhardja, Thomas Surya ; Lippey, Jocelyn ; Keane, Holly ; Tan, Kian Jin ; Clouston, David ; Gorelik, Alexandra ; Mann, Gregory Bruce ; Fox, Jane ; The Melbourne Breast Group ; Speakman, David. / Management of Early Node-Positive Breast Cancer in Australia : A Multicentre Study. In: The Breast Journal. 2016 ; Vol. 22, No. 4. pp. 413-419.
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abstract = "To examine practice patterns for breast cancer patients with limited sentinel node (SN) disease in light of the ACOSOG Z0011 results. Retrospective analysis of patients with T1-2 breast cancer and positive sentinel lymph node biopsy (SLNB) admitted between January 2009 and December 2012. Patient demographics, tumor characteristics, and treatments were recorded. Eight hundred positive SLNBs were identified. A total of 452 (56.5{\%}) proceeded to completion axillary lymph node dissection (cALND). cALND rate decreased from 65.1{\%} to 49.7{\%} from 2009–2010 to 2011–2012. cALND was performed for micrometastasis or isolated tumor cells in 39.3{\%} in 2009–2010 and 22.2{\%} in 2011–2012, whereas for macrometastases the rates were 83.1{\%} and 68.6{\%}, respectively. cALND rates diminished for both Z0011-eligible and -ineligible patients. The ACOSOG Z0011 trial presentation and publication coincided with a reduction in cALND for breast cancer with limited nodal disease. There appears equipoise regarding management of macrometastatic SN disease.",
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Gannan, E, Khoo, J, Nightingale, SS, Suhardja, TS, Lippey, J, Keane, H, Tan, KJ, Clouston, D, Gorelik, A, Mann, GB, Fox, J, The Melbourne Breast Group & Speakman, D 2016, 'Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study', The Breast Journal, vol. 22, no. 4, pp. 413-419. https://doi.org/10.1111/tbj.12595

Management of Early Node-Positive Breast Cancer in Australia : A Multicentre Study. / Gannan, Emma; Khoo, Jeremy; Nightingale, Sophie S; Suhardja, Thomas Surya; Lippey, Jocelyn; Keane, Holly; Tan, Kian Jin; Clouston, David; Gorelik, Alexandra; Mann, Gregory Bruce; Fox, Jane; The Melbourne Breast Group; Speakman, David.

In: The Breast Journal, Vol. 22, No. 4, 01.07.2016, p. 413-419.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - To examine practice patterns for breast cancer patients with limited sentinel node (SN) disease in light of the ACOSOG Z0011 results. Retrospective analysis of patients with T1-2 breast cancer and positive sentinel lymph node biopsy (SLNB) admitted between January 2009 and December 2012. Patient demographics, tumor characteristics, and treatments were recorded. Eight hundred positive SLNBs were identified. A total of 452 (56.5%) proceeded to completion axillary lymph node dissection (cALND). cALND rate decreased from 65.1% to 49.7% from 2009–2010 to 2011–2012. cALND was performed for micrometastasis or isolated tumor cells in 39.3% in 2009–2010 and 22.2% in 2011–2012, whereas for macrometastases the rates were 83.1% and 68.6%, respectively. cALND rates diminished for both Z0011-eligible and -ineligible patients. The ACOSOG Z0011 trial presentation and publication coincided with a reduction in cALND for breast cancer with limited nodal disease. There appears equipoise regarding management of macrometastatic SN disease.

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Gannan E, Khoo J, Nightingale SS, Suhardja TS, Lippey J, Keane H et al. Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study. The Breast Journal. 2016 Jul 1;22(4):413-419. https://doi.org/10.1111/tbj.12595