Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study

Emma Gannan, Jeremy Khoo, Sophie S Nightingale, Thomas Surya Suhardja, Jocelyn Lippey, Holly Keane, Kian Jin Tan, David Clouston, Alexandra Gorelik, Gregory Bruce Mann, Jane Fox, The Melbourne Breast Group, David Speakman

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To examine practice patterns for breast cancer patients with limited sentinel node (SN) disease in light of the ACOSOG Z0011 results. Retrospective analysis of patients with T1-2 breast cancer and positive sentinel lymph node biopsy (SLNB) admitted between January 2009 and December 2012. Patient demographics, tumor characteristics, and treatments were recorded. Eight hundred positive SLNBs were identified. A total of 452 (56.5%) proceeded to completion axillary lymph node dissection (cALND). cALND rate decreased from 65.1% to 49.7% from 2009–2010 to 2011–2012. cALND was performed for micrometastasis or isolated tumor cells in 39.3% in 2009–2010 and 22.2% in 2011–2012, whereas for macrometastases the rates were 83.1% and 68.6%, respectively. cALND rates diminished for both Z0011-eligible and -ineligible patients. The ACOSOG Z0011 trial presentation and publication coincided with a reduction in cALND for breast cancer with limited nodal disease. There appears equipoise regarding management of macrometastatic SN disease.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalThe Breast Journal
Issue number4
Publication statusPublished - 1 Jul 2016


  • ACOSOG Z0011 trial
  • axillary lymph node dissection
  • breast cancer
  • sentinel lymph node biopsy

Cite this

Gannan, E., Khoo, J., Nightingale, S. S., Suhardja, T. S., Lippey, J., Keane, H., Tan, K. J., Clouston, D., Gorelik, A., Mann, G. B., Fox, J., The Melbourne Breast Group, & Speakman, D. (2016). Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study. The Breast Journal, 22(4), 413-419.