Management of breast cancer with nanoparticle albumin-bound (nab)-paclitaxel combination regimens: A clinical review

J. Chirgwin, S. L. Chua

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Monotherapy with nanoparticle albumin-bound (nab)-paclitaxel has demonstrated improved efficacy and safety compared with solvent-based paclitaxel and docetaxel. Design: A comprehensive review of all reported studies of nab-paclitaxel combinations with other agents in all breast cancer settings was undertaken. Results: Most studies reviewed are small, phase II and non-comparative. Combinations studied included nab-paclitaxel plus trastuzumab and/or bevacizumab (with or without additional cytotoxic agents), gemcitabine, capecitabine, carboplatin, or lapatinib. The majority of metastatic and neoadjuvant studies demonstrated satisfactory efficacy and safety for nab-paclitaxel combinations, although conclusions regarding comparison with solvent-based taxane (SBT) regimens are not possible. The two adjuvant studies confirmed the safety of nab-paclitaxel combinations in this setting. Conclusions: Although results of this review indicate that nab-paclitaxel may be an appropriate substitute for SBTs in combination regimens, additional research is required to confirm the place and cost effectiveness of these combinations before nab-paclitaxel could be recommended routinely in all settings.

Original languageEnglish
Pages (from-to)394-406
Number of pages13
JournalThe Breast
Volume20
Issue number5
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Keywords

  • 130-nm albumin-bound paclitaxel
  • Adjuvant chemotherapy
  • Breast neoplasms
  • Neoadjuvant therapy
  • Neoplasm metastasis
  • Taxane

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