TY - JOUR
T1 - Management and outcome of mechanically ventilated patients after cardiac arrest
AU - Sutherasan, Yuda
AU - Penuelas, Oscar
AU - Muriel, Alfonso
AU - Vargas, Maria
AU - Frutos-Vivar, Fernando
AU - Brunetti, Iole
AU - Raymondos, Konstantinos
AU - D'Antini, Davide
AU - Nielsen, Niklas
AU - Ferguson, Niall
AU - Bottiger, Bernd W
AU - Thille, Arnaud W
AU - Davies, Andrew Ross
AU - Hurtado, Francisco Javier
AU - Rios, Fernando
AU - Apezteguia, Carlos
AU - Violi, Damian A
AU - Cakar, Nahit
AU - Gonzalez, Marco
AU - Du, Bin
AU - Kuiper, Michael A
AU - Soares, Marco Antonio
AU - Koh, Younsuck
AU - Moreno, Rui Paulo
AU - Amin, Pravin
AU - Tomicic, Vinko
AU - Soto, Luis
AU - Bulow, Hans-Henrik
AU - Anzueto, Antonio
AU - Esteban, Andres
AU - Pelosi, Paolo
PY - 2015
Y1 - 2015
N2 - Introduction: The aim of this study was to describe and compare the changes in ventilator management and complications over time, as well as variables associated with 28-day hospital mortality in patients receiving mechanical ventilation (MV) after cardiac arrest. Methods: We performed a secondary analysis of three prospective, observational multicenter studies conducted in 1998, 2004 and 2010 in 927 ICUs from 40 countries. We screened 18,302 patients receiving MV for more than 12 hours during a one-month-period. We included 812 patients receiving MV after cardiac arrest. We collected data on demographics, daily ventilator settings, complications during ventilation and outcomes. Multivariate logistic regression analysis was performed to calculate odds ratios, determining which variables within 24 hours of hospital admission were associated with 28-day hospital mortality and occurrence of acute respiratory distress syndrome (ARDS) and pneumonia acquired during ICU stay at 48 hours after admission. Results: Among 812 patients, 100 were included from 1998, 239 from 2004 and 473 from 2010. Ventilatory management changed over time, with decreased tidal volumes (VT) (1998: mean 8.9 (standard deviation (SD) 2) ml/kg actual body weight (ABW), 2010: 6.7 (SD 2) ml/kg ABW; 2004: 9 (SD 2.3) ml/kg predicted body weight (PBW), 2010: 7.95 (SD 1.7) ml/kg PBW) and increased positive end-expiratory pressure (PEEP) (1998: mean 3.5 (SD 3), 2010: 6.5 (SD 3); P
AB - Introduction: The aim of this study was to describe and compare the changes in ventilator management and complications over time, as well as variables associated with 28-day hospital mortality in patients receiving mechanical ventilation (MV) after cardiac arrest. Methods: We performed a secondary analysis of three prospective, observational multicenter studies conducted in 1998, 2004 and 2010 in 927 ICUs from 40 countries. We screened 18,302 patients receiving MV for more than 12 hours during a one-month-period. We included 812 patients receiving MV after cardiac arrest. We collected data on demographics, daily ventilator settings, complications during ventilation and outcomes. Multivariate logistic regression analysis was performed to calculate odds ratios, determining which variables within 24 hours of hospital admission were associated with 28-day hospital mortality and occurrence of acute respiratory distress syndrome (ARDS) and pneumonia acquired during ICU stay at 48 hours after admission. Results: Among 812 patients, 100 were included from 1998, 239 from 2004 and 473 from 2010. Ventilatory management changed over time, with decreased tidal volumes (VT) (1998: mean 8.9 (standard deviation (SD) 2) ml/kg actual body weight (ABW), 2010: 6.7 (SD 2) ml/kg ABW; 2004: 9 (SD 2.3) ml/kg predicted body weight (PBW), 2010: 7.95 (SD 1.7) ml/kg PBW) and increased positive end-expiratory pressure (PEEP) (1998: mean 3.5 (SD 3), 2010: 6.5 (SD 3); P
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457998/pdf/13054_2015_Article_922.pdf
U2 - 10.1186/s13054-015-0922-9
DO - 10.1186/s13054-015-0922-9
M3 - Article
SN - 1364-8535
VL - 19
SP - 1
EP - 11
JO - Critical Care
JF - Critical Care
IS - 1 (Art. No: 215)
ER -