Mammary stem cells and parity-induced breast cancer protection- new insights

Genevieve Dall, Gail Risbridger, Kara Britt

Research output: Contribution to journalReview ArticleOtherpeer-review

8 Citations (Scopus)

Abstract

Parity (childbearing) significantly decreases a woman’s risk of breast cancer and the protective effect is greater if the woman is younger and has more children. The mechanism/s of parity-induced protection are not known. Although several factors are postulated to play a role, we discuss how a reduction in the number of mammary stem cells (MaSCs) may lead to a reduction in breast cancer risk in parous women. Firstly we review the epidemiology linking childbearing to reduced breast cancer risk and discuss how additional births, a young age at first full term birth, and breastfeeding impact the protection. We then detail the mouse and human studies implicating MaSC in parity induced protection and the in-vivo work being performed in mice to directly investigate the effect of parity on MaSC. Finally we discuss the transplant and lineage tracing experiments assessing MaSC activity according to parity and the need to define if MaSC are indeed more carcinogen sensitive than mature mammary epithelial cells. Continuing and future studies attempting to define the parity induced mechanisms will aid in the development of preventative therapies.
Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume170
DOIs
Publication statusPublished - Jun 2017

Keywords

  • breast cancer
  • parity
  • mammary stem cells

Cite this

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abstract = "Parity (childbearing) significantly decreases a woman’s risk of breast cancer and the protective effect is greater if the woman is younger and has more children. The mechanism/s of parity-induced protection are not known. Although several factors are postulated to play a role, we discuss how a reduction in the number of mammary stem cells (MaSCs) may lead to a reduction in breast cancer risk in parous women. Firstly we review the epidemiology linking childbearing to reduced breast cancer risk and discuss how additional births, a young age at first full term birth, and breastfeeding impact the protection. We then detail the mouse and human studies implicating MaSC in parity induced protection and the in-vivo work being performed in mice to directly investigate the effect of parity on MaSC. Finally we discuss the transplant and lineage tracing experiments assessing MaSC activity according to parity and the need to define if MaSC are indeed more carcinogen sensitive than mature mammary epithelial cells. Continuing and future studies attempting to define the parity induced mechanisms will aid in the development of preventative therapies.",
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Mammary stem cells and parity-induced breast cancer protection- new insights. / Dall, Genevieve; Risbridger, Gail; Britt, Kara.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 170, 06.2017, p. 54-60.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - Mammary stem cells and parity-induced breast cancer protection- new insights

AU - Dall, Genevieve

AU - Risbridger, Gail

AU - Britt, Kara

PY - 2017/6

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N2 - Parity (childbearing) significantly decreases a woman’s risk of breast cancer and the protective effect is greater if the woman is younger and has more children. The mechanism/s of parity-induced protection are not known. Although several factors are postulated to play a role, we discuss how a reduction in the number of mammary stem cells (MaSCs) may lead to a reduction in breast cancer risk in parous women. Firstly we review the epidemiology linking childbearing to reduced breast cancer risk and discuss how additional births, a young age at first full term birth, and breastfeeding impact the protection. We then detail the mouse and human studies implicating MaSC in parity induced protection and the in-vivo work being performed in mice to directly investigate the effect of parity on MaSC. Finally we discuss the transplant and lineage tracing experiments assessing MaSC activity according to parity and the need to define if MaSC are indeed more carcinogen sensitive than mature mammary epithelial cells. Continuing and future studies attempting to define the parity induced mechanisms will aid in the development of preventative therapies.

AB - Parity (childbearing) significantly decreases a woman’s risk of breast cancer and the protective effect is greater if the woman is younger and has more children. The mechanism/s of parity-induced protection are not known. Although several factors are postulated to play a role, we discuss how a reduction in the number of mammary stem cells (MaSCs) may lead to a reduction in breast cancer risk in parous women. Firstly we review the epidemiology linking childbearing to reduced breast cancer risk and discuss how additional births, a young age at first full term birth, and breastfeeding impact the protection. We then detail the mouse and human studies implicating MaSC in parity induced protection and the in-vivo work being performed in mice to directly investigate the effect of parity on MaSC. Finally we discuss the transplant and lineage tracing experiments assessing MaSC activity according to parity and the need to define if MaSC are indeed more carcinogen sensitive than mature mammary epithelial cells. Continuing and future studies attempting to define the parity induced mechanisms will aid in the development of preventative therapies.

KW - breast cancer

KW - parity

KW - mammary stem cells

UR - http://www.ncbi.nlm.nih.gov/pubmed/26907964

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DO - 10.1016/j.jsbmb.2016.02.018

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JO - Journal of Steroid Biochemistry and Molecular Biology

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SN - 0960-0760

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