Mammalian sex determination and gonad development

Dagmar Wilhelm, Jennifer Xuelian Yang, Paul Thomas

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

From a developmental biology perspective, gonadogenesis is of particular interest because it provides a unique example of how distinct organs, the testis and ovary, can arise from a common bipotential primordium. Gonadogenesis is also highly relevant from a clinical perspective, as congenital disorders of sex development (DSDs) are not uncommon, occurring in approximately 1 in 4500 live births. In recent years, there has been significant progress in our understanding of the genes and pathways that control important aspects of gonadogenesis including the initial decision to develop as a testis or ovary (sex determination), elaboration and cross-repression of the testis and ovary developmental pathways, and maintenance of the gonadal phenotype after birth. In this chapter, we provide an overview of gonadal morphogenesis and cell lineage specification, focusing primarily on these processes in mice and humans. We also provide an update on the genetic mechanisms that control murine gonadogenesis and maintenance and, where possible, discuss new insights into the pathological mechanisms of DSDs associated with mutation of orthologous genes in mice and humans.
Original languageEnglish
Pages (from-to)89 - 121
Number of pages33
JournalCurrent Topics in Developmental Biology
Volume106
DOIs
Publication statusPublished - 2013

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