TY - JOUR
T1 - Mammalian rest/activity patterns explained by physiologically based modeling
AU - Phillips, Andrew J K
AU - Fulcher, Ben
AU - Robinson, Peter Alexander
AU - Klerman, Elizabeth
PY - 2013
Y1 - 2013
N2 - Circadian rhythms are fundamental to life. In mammals, these rhythms are generated by pacemaker neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is remarkably consistent in structure and function between species, yet mammalian rest/activity patterns are extremely diverse, including diurnal, nocturnal, and crepuscular behaviors. Two mechanisms have been proposed to account for this diversity: (i) modulation of SCN output by downstream nuclei, and (ii) direct effects of light on activity.
AB - Circadian rhythms are fundamental to life. In mammals, these rhythms are generated by pacemaker neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is remarkably consistent in structure and function between species, yet mammalian rest/activity patterns are extremely diverse, including diurnal, nocturnal, and crepuscular behaviors. Two mechanisms have been proposed to account for this diversity: (i) modulation of SCN output by downstream nuclei, and (ii) direct effects of light on activity.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764015/
U2 - 10.1371/journal.pcbi.1003213
DO - 10.1371/journal.pcbi.1003213
M3 - Article
SN - 1553-734X
VL - 9
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 9
M1 - e1003213
ER -