TY - JOUR
T1 - Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS
AU - Ribbons, Karen Ann
AU - McElduff, Patrick
AU - Boz, Cavit
AU - Trojano, Maria
AU - Izquierdo, Guillermo
AU - Duquette, Pierre
AU - Girard, Marc
AU - Grand'Maison, Francois
AU - Hupperts, Raymond
AU - Grammond, Pierre
AU - Oreja-Guevara, Celia
AU - Petersen, Thor
AU - Bergamaschi, Roberto
AU - Giuliani, Giorgio
AU - Barnett, Michael
AU - Van Pesch, Vincent
AU - Amato, Maria Pia
AU - Iuliano, Gerardo
AU - Fiol, Marcela
AU - Slee, Mark
AU - Verheul, Freek
AU - Cristiano, Edgardo
AU - Fernandez-Bolanos, Ricardo
AU - Saladino, Maria Laura
AU - Rio, Maria Edite
AU - Cabrera-Gomez, Jose
AU - Butzkueven, Helmut
AU - Van Munster, Erik
AU - Braber-Moerland, Leontien Den
AU - Spitaleri, Daniele La
AU - Lugaresi, Alessandra
AU - Shaygannejad, Vahid
AU - Gray, Orla
AU - Deri, Norma
AU - Alroughani, Raed
AU - Lechner-Scott, Jeannette
PY - 2015/6/5
Y1 - 2015/6/5
N2 - Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change. Conclusion: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar.
AB - Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change. Conclusion: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar.
UR - http://www.scopus.com/inward/record.url?scp=84934938814&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0122686
DO - 10.1371/journal.pone.0122686
M3 - Article
C2 - 26046348
AN - SCOPUS:84934938814
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0122686
ER -