Malaysian cobra venom: A potential source of anti-cancer therapeutic agents

Syafiq Asnawi Zainal Abidin, Yee Qian Lee, Iekhsan Othman, Rakesh Naidu

    Research output: Contribution to journalReview ArticleResearchpeer-review

    7 Citations (Scopus)

    Abstract

    Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived anticancer agents. Malaysia is one of the world’s most biodiverse countries and is home to various venomous snake species, including cobras. Naja kaouthia, Naja sumatrana, and Ophiophagus hannah are three of the most common cobra species in Malaysia and are of medical importance. Over the past decades, snake venom has been identified as a potential source of therapeutic agents, including anti-cancer agents. This present review highlights the potential anticancer activity of the venom and purified venom protein of N. kaouthia, N. sumatrana, and O. hannah. In conclusion, this review highlights the important role of the venom from Malaysian cobras as an important resource that researchers can exploit to further investigate its potential in cancer treatment.

    Original languageEnglish
    Article number75
    Number of pages12
    JournalToxins
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - Feb 2019

    Keywords

    • Anticancer
    • Malaysian cobras
    • N. kaouthia
    • N. sumatrana
    • O. hannah
    • Snake venom

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