TY - JOUR
T1 - Malaysian cobra venom
T2 - A potential source of anti-cancer therapeutic agents
AU - Abidin, Syafiq Asnawi Zainal
AU - Lee, Yee Qian
AU - Othman, Iekhsan
AU - Naidu, Rakesh
N1 - Funding Information:
This research received no external funding. We would like to thank Mr. Zainuddin Ismail (Bukit Bintang Enterprise, Perlis) for his expertise and advice in snake handling. Y.Q.L. is supported by Monash University Malaysia through a merit scholarship for their master’s study.
Funding Information:
Acknowledgments: We would like to thank Mr. Zainuddin Ismail (Bukit Bintang Enterprise, Perlis) for his expertise and advice in snake handling. Y.Q.L. is supported by Monash University Malaysia through a merit scholarship for their master’s study.
Publisher Copyright:
© 2019 by the authors.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/2
Y1 - 2019/2
N2 - Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived anticancer agents. Malaysia is one of the world’s most biodiverse countries and is home to various venomous snake species, including cobras. Naja kaouthia, Naja sumatrana, and Ophiophagus hannah are three of the most common cobra species in Malaysia and are of medical importance. Over the past decades, snake venom has been identified as a potential source of therapeutic agents, including anti-cancer agents. This present review highlights the potential anticancer activity of the venom and purified venom protein of N. kaouthia, N. sumatrana, and O. hannah. In conclusion, this review highlights the important role of the venom from Malaysian cobras as an important resource that researchers can exploit to further investigate its potential in cancer treatment.
AB - Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived anticancer agents. Malaysia is one of the world’s most biodiverse countries and is home to various venomous snake species, including cobras. Naja kaouthia, Naja sumatrana, and Ophiophagus hannah are three of the most common cobra species in Malaysia and are of medical importance. Over the past decades, snake venom has been identified as a potential source of therapeutic agents, including anti-cancer agents. This present review highlights the potential anticancer activity of the venom and purified venom protein of N. kaouthia, N. sumatrana, and O. hannah. In conclusion, this review highlights the important role of the venom from Malaysian cobras as an important resource that researchers can exploit to further investigate its potential in cancer treatment.
KW - Anticancer
KW - Malaysian cobras
KW - N. kaouthia
KW - N. sumatrana
KW - O. hannah
KW - Snake venom
UR - http://www.scopus.com/inward/record.url?scp=85061147271&partnerID=8YFLogxK
U2 - 10.3390/toxins11020075
DO - 10.3390/toxins11020075
M3 - Review Article
C2 - 30717096
AN - SCOPUS:85061147271
SN - 2072-6651
VL - 11
JO - Toxins
JF - Toxins
IS - 2
M1 - 75
ER -
