Malaria and age variably but critically control hepcidin throughout childhood in Kenya

Sarah H Atkinson; Sophie M Uyoga; Andrew E Armitage; Shivani Khandwala; Cleopatra K Mugyenyi; Philip A Bejon; Kevin Marsh; James G Beeson; Andrew M Prentice; Hal Drakesmith; Thomas N Williams

doi:10.1016/j.ebiom.2015.08.016

Malaria and age variably but critically control hepcidin throughout childhood in Kenya

Sarah H Atkinson, Sophie M Uyoga, Andrew E Armitage, Shivani Khandwala, Cleopatra K Mugyenyi, Philip A Bejon, Kevin Marsh, James G Beeson, Andrew M Prentice, Hal Drakesmith, Thomas N Williams

Microbiology

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

Both iron deficiency (ID) and malaria are common among African children. Studies show that the iron-regulatory hormone hepcidin is induced by malaria, but few studies have investigated this relationship longitudinally. We measured hepcidin concentrations, markers of iron status, and antibodies to malaria antigens during two cross-sectional surveys within a cohort of 324 Kenyan children

Original language	English
Pages (from-to)	1478 - 1486
Number of pages	9
Journal	EBioMedicine
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.ebiom.2015.08.016
Publication status	Published - 2015

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3570052-oaFinal published version, 1.07 MBLicence: CC BY

Cite this

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AU - Atkinson, Sarah H

AU - Uyoga, Sophie M

AU - Armitage, Andrew E

AU - Khandwala, Shivani

AU - Mugyenyi, Cleopatra K

AU - Bejon, Philip A

AU - Marsh, Kevin

AU - Beeson, James G

AU - Prentice, Andrew M

AU - Drakesmith, Hal

AU - Williams, Thomas N

PY - 2015

Y1 - 2015

N2 - Both iron deficiency (ID) and malaria are common among African children. Studies show that the iron-regulatory hormone hepcidin is induced by malaria, but few studies have investigated this relationship longitudinally. We measured hepcidin concentrations, markers of iron status, and antibodies to malaria antigens during two cross-sectional surveys within a cohort of 324 Kenyan children

AB - Both iron deficiency (ID) and malaria are common among African children. Studies show that the iron-regulatory hormone hepcidin is induced by malaria, but few studies have investigated this relationship longitudinally. We measured hepcidin concentrations, markers of iron status, and antibodies to malaria antigens during two cross-sectional surveys within a cohort of 324 Kenyan children

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634196/pdf/main.pdf

U2 - 10.1016/j.ebiom.2015.08.016

DO - 10.1016/j.ebiom.2015.08.016

M3 - Article

VL - 2

SP - 1478

EP - 1486

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

IS - 10

ER -

Malaria and age variably but critically control hepcidin throughout childhood in Kenya

Abstract

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