Malaria and age variably but critically control hepcidin throughout childhood in Kenya

Sarah H Atkinson, Sophie M Uyoga, Andrew E Armitage, Shivani Khandwala, Cleopatra K Mugyenyi, Philip A Bejon, Kevin Marsh, James G Beeson, Andrew M Prentice, Hal Drakesmith, Thomas N Williams

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15 Citations (Scopus)

Abstract

Both iron deficiency (ID) and malaria are common among African children. Studies show that the iron-regulatory hormone hepcidin is induced by malaria, but few studies have investigated this relationship longitudinally. We measured hepcidin concentrations, markers of iron status, and antibodies to malaria antigens during two cross-sectional surveys within a cohort of 324 Kenyan children
Original languageEnglish
Pages (from-to)1478 - 1486
Number of pages9
JournalEBioMedicine
Volume2
Issue number10
DOIs
Publication statusPublished - 2015

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