TY - JOUR
T1 - Making sense of plasma cell heterogeneity
AU - Tarlinton, David M.
AU - Ding, Zhoujie
AU - Tellier, Julie
AU - Nutt, Stephen L.
N1 - Funding Information:
This work was supported by the National Health and Medical Research Council Australia ( 1155342 to S.L.N; 1175411 to D.M.T.) and the Cancer Council Victoria grant-in-aid (to J.T. and S.L.N.).
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/4
Y1 - 2023/4
N2 - Plasma cells (PCs) are essential for the quality and longevity of protective immunity. The canonical humoral response to vaccination involves induction of germinal centers in lymph nodes followed by maintenance by bone marrow-resident PCs, although there are many variations of this theme. Recent studies have highlighted the importance of PCs in nonlymphoid organs, including the gut, central nervous system, and skin. These sites harbor PCs with distinct isotypes and possible immunoglobulin-independent functions. Indeed, bone marrow now appears unique in housing PCs derived from multiple other organs. The mechanisms through which the bone marrow maintains PC survival long-term and the impact of their diverse origins on this process remain very active areas of research.
AB - Plasma cells (PCs) are essential for the quality and longevity of protective immunity. The canonical humoral response to vaccination involves induction of germinal centers in lymph nodes followed by maintenance by bone marrow-resident PCs, although there are many variations of this theme. Recent studies have highlighted the importance of PCs in nonlymphoid organs, including the gut, central nervous system, and skin. These sites harbor PCs with distinct isotypes and possible immunoglobulin-independent functions. Indeed, bone marrow now appears unique in housing PCs derived from multiple other organs. The mechanisms through which the bone marrow maintains PC survival long-term and the impact of their diverse origins on this process remain very active areas of research.
UR - http://www.scopus.com/inward/record.url?scp=85149481310&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2023.102297
DO - 10.1016/j.coi.2023.102297
M3 - Review Article
C2 - 36889029
AN - SCOPUS:85149481310
SN - 0952-7915
VL - 81
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
M1 - 102297
ER -
