Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice

Kristy Larissa Jackson, Kesia Palma-Rigo, Thu-Phuc Nguyen-Huu, Pamela J Davern, Geoffrey A Head

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BPH/2J mice are recognized as a neurogenic model of hypertension primarily based on overactivity of the sympathetic nervous system and greater neuronal activity in key autonomic cardiovascular regulatory brain regions. The medial amygdala (MeAm) is a forebrain region that integrates the autonomic response to stress and is the only region found to have greater Fos during the night and daytime in BPH/2J compared with BPN/3J mice. To determine the contribution of the MeAm to hypertension, the effect of neuronal ablation on blood pressure (BP) was assessed in BPH/2J (n=7) and normotensive BPN/3J mice (n=7). Mice were preimplanted with radiotelemetry devices to measure 24-hour BP and cardiovascular responses to stress, before and 1 to 3 weeks after bilateral lesions of the MeAm. Baseline BP was 121+/-4 mm Hg in BPH/2J and 101+/-2 mm Hg in BPN/3J mice (Pstrain
Original languageEnglish
Pages (from-to)811 - 818
Number of pages8
JournalHypertension
Volume63
Issue number4
DOIs
Publication statusPublished - 2014

Cite this

Jackson, Kristy Larissa ; Palma-Rigo, Kesia ; Nguyen-Huu, Thu-Phuc ; Davern, Pamela J ; Head, Geoffrey A. / Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice. In: Hypertension. 2014 ; Vol. 63, No. 4. pp. 811 - 818.
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abstract = "BPH/2J mice are recognized as a neurogenic model of hypertension primarily based on overactivity of the sympathetic nervous system and greater neuronal activity in key autonomic cardiovascular regulatory brain regions. The medial amygdala (MeAm) is a forebrain region that integrates the autonomic response to stress and is the only region found to have greater Fos during the night and daytime in BPH/2J compared with BPN/3J mice. To determine the contribution of the MeAm to hypertension, the effect of neuronal ablation on blood pressure (BP) was assessed in BPH/2J (n=7) and normotensive BPN/3J mice (n=7). Mice were preimplanted with radiotelemetry devices to measure 24-hour BP and cardiovascular responses to stress, before and 1 to 3 weeks after bilateral lesions of the MeAm. Baseline BP was 121+/-4 mm Hg in BPH/2J and 101+/-2 mm Hg in BPN/3J mice (Pstrain",
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Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice. / Jackson, Kristy Larissa; Palma-Rigo, Kesia; Nguyen-Huu, Thu-Phuc; Davern, Pamela J; Head, Geoffrey A.

In: Hypertension, Vol. 63, No. 4, 2014, p. 811 - 818.

Research output: Contribution to journalArticleResearchpeer-review

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