MAIT cells and MR1-antigen recognition

Andrew N Keller, Alexandra J. Corbett, Jacinta M Wubben, James McCluskey, Jamie Rossjohn

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector potential. Recent data demonstrates how: vitamin B precursors modulate intracellular trafficking of MR1 and impact on MAIT cell development; variation in the MAIT cell antigen receptor sequence impacts MR1-antigen recognition; and most notably, how MR1 can capture chemical identities distinct from riboflavin precursors, including drugs and drug-like molecules. With mounting evidence demonstrating their roles in immunity and pathology, understanding the MAIT-MR1-antigen axis may have profound implications for human diseases.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalCurrent Opinion in Immunology
Volume46
DOIs
Publication statusPublished - 1 Jun 2017

Cite this

Keller, Andrew N ; Corbett, Alexandra J. ; Wubben, Jacinta M ; McCluskey, James ; Rossjohn, Jamie. / MAIT cells and MR1-antigen recognition. In: Current Opinion in Immunology. 2017 ; Vol. 46. pp. 66-74.
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MAIT cells and MR1-antigen recognition. / Keller, Andrew N; Corbett, Alexandra J.; Wubben, Jacinta M; McCluskey, James; Rossjohn, Jamie.

In: Current Opinion in Immunology, Vol. 46, 01.06.2017, p. 66-74.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Keller, Andrew N

AU - Corbett, Alexandra J.

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AB - Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector potential. Recent data demonstrates how: vitamin B precursors modulate intracellular trafficking of MR1 and impact on MAIT cell development; variation in the MAIT cell antigen receptor sequence impacts MR1-antigen recognition; and most notably, how MR1 can capture chemical identities distinct from riboflavin precursors, including drugs and drug-like molecules. With mounting evidence demonstrating their roles in immunity and pathology, understanding the MAIT-MR1-antigen axis may have profound implications for human diseases.

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