Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment

Jacqueline K Flynn, Gregory J Dore, Margaret Hellard, Barbara Yeung, William Rawlinson, Peter A White, John M Kaldor, Andrew Lloyd, Rosemary Ann Ffrench

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Abstract

Background and Aim: T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1 and Th2 hepatitis C virus (HCV)-specific cytokine production and T-cell effector function from subjects enrolled in the Australian Trial in Acute Hepatitis C comparing three groups: treatment-induced clearance (sustained virological response [SVR]), treatment non-response, and untreated spontaneous clearance. Methods: HCV-specific T-cell responses were characterized by HCV peptide ELISpot, in vitro cytokine production, and T-cell flow cytometry assays. Results: Treated subjects with a sustained virological response (SVR) displayed a better maintenance of HCV-specific Th1 responses compared to treatment non-responders (higher interferon [IFN]-? and interleukin (IL)-2 magnitude at week 24, broader IFN-? responses at weeks 24 and 48, P
Original languageEnglish
Pages (from-to)1770 - 1781
Number of pages12
JournalJournal of Gastroenterology and Hepatology
Volume28
Issue number11
DOIs
Publication statusPublished - 2013

Cite this

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title = "Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment",
abstract = "Background and Aim: T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1 and Th2 hepatitis C virus (HCV)-specific cytokine production and T-cell effector function from subjects enrolled in the Australian Trial in Acute Hepatitis C comparing three groups: treatment-induced clearance (sustained virological response [SVR]), treatment non-response, and untreated spontaneous clearance. Methods: HCV-specific T-cell responses were characterized by HCV peptide ELISpot, in vitro cytokine production, and T-cell flow cytometry assays. Results: Treated subjects with a sustained virological response (SVR) displayed a better maintenance of HCV-specific Th1 responses compared to treatment non-responders (higher interferon [IFN]-? and interleukin (IL)-2 magnitude at week 24, broader IFN-? responses at weeks 24 and 48, P",
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pages = "1770 -- 1781",
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Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment. / Flynn, Jacqueline K; Dore, Gregory J; Hellard, Margaret; Yeung, Barbara; Rawlinson, William; White, Peter A; Kaldor, John M; Lloyd, Andrew; Ffrench, Rosemary Ann.

In: Journal of Gastroenterology and Hepatology, Vol. 28, No. 11, 2013, p. 1770 - 1781.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment

AU - Flynn, Jacqueline K

AU - Dore, Gregory J

AU - Hellard, Margaret

AU - Yeung, Barbara

AU - Rawlinson, William

AU - White, Peter A

AU - Kaldor, John M

AU - Lloyd, Andrew

AU - Ffrench, Rosemary Ann

PY - 2013

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N2 - Background and Aim: T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1 and Th2 hepatitis C virus (HCV)-specific cytokine production and T-cell effector function from subjects enrolled in the Australian Trial in Acute Hepatitis C comparing three groups: treatment-induced clearance (sustained virological response [SVR]), treatment non-response, and untreated spontaneous clearance. Methods: HCV-specific T-cell responses were characterized by HCV peptide ELISpot, in vitro cytokine production, and T-cell flow cytometry assays. Results: Treated subjects with a sustained virological response (SVR) displayed a better maintenance of HCV-specific Th1 responses compared to treatment non-responders (higher interferon [IFN]-? and interleukin (IL)-2 magnitude at week 24, broader IFN-? responses at weeks 24 and 48, P

AB - Background and Aim: T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1 and Th2 hepatitis C virus (HCV)-specific cytokine production and T-cell effector function from subjects enrolled in the Australian Trial in Acute Hepatitis C comparing three groups: treatment-induced clearance (sustained virological response [SVR]), treatment non-response, and untreated spontaneous clearance. Methods: HCV-specific T-cell responses were characterized by HCV peptide ELISpot, in vitro cytokine production, and T-cell flow cytometry assays. Results: Treated subjects with a sustained virological response (SVR) displayed a better maintenance of HCV-specific Th1 responses compared to treatment non-responders (higher interferon [IFN]-? and interleukin (IL)-2 magnitude at week 24, broader IFN-? responses at weeks 24 and 48, P

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