Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection

Laura K. Mackay, Linda Wakim, Catherine J. Van Vliet, Claerwen M. Jones, Scott N. Mueller, Oliver Bannard, Douglas T. Fearon, William R. Heath, Francis R. Carbone

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Abstract

Persisting infections are often associated with chronic T cell activation. For certain pathogens, this can lead to T cell exhaustion and survival of what is otherwise a cleared infection. In contrast, for herpesviruses, T cells never eliminate infection once it is established. Instead, effective immunity appears to maintain these pathogens in a state of latency. We used infection with HSV to examine whether effector-type T cells undergoing chronic stimulation retained functional and proliferative capacity during latency and subsequent reactivation. We found that latency-associated T cells exhibited a polyfunctional phenotype and could secrete a range of effector cytokines. These T cells were also capable of mounting a recall proliferative response on HSV reactivation and could do so repeatedly. Thus, for this latent infection, T cells subjected to chronic Ag stimulation and periodic reactivation retain the ability to respond to local virus challenge. 

Original languageEnglish
Pages (from-to)2173-2178
Number of pages6
JournalJournal of Immunology
Volume188
Issue number5
DOIs
Publication statusPublished - 1 Mar 2012
Externally publishedYes

Cite this

Mackay, L. K., Wakim, L., Van Vliet, C. J., Jones, C. M., Mueller, S. N., Bannard, O., Fearon, D. T., Heath, W. R., & Carbone, F. R. (2012). Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. Journal of Immunology, 188(5), 2173-2178. https://doi.org/10.4049/jimmunol.1102719