Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds

Megan Heffernan, Gavin Andrews, Maria A. Fiatarone Singh, Michael Valenzuela, Kaarin J. Anstey, Anthony J. Maeder, John McNeil, Louisa Jorm, Nicola T. Lautenschlager, Perminder S. Sachdev, Jeewani A. Ginige, Megan J. Hobbs, Christos Boulamatsis, Tiffany Chau, Lynne Cobiac, Kay L. Cox, Kenneth Daniel, Victoria M. Flood, Yareni Guerrero, Jane GunnNidhi Jain, Nicole A. Kochan, Amit Lampit, Yorgi Mavros, Jacinda Meiklejohn, Yian Noble, Fiona O'Leary, Sue Radd-Vagenas, Courtney C. Walton, Henry Brodaty, Maintain Your Brain Collaborative Team

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


Background: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. Methods: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial. Discussion: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.

Original languageEnglish
Pages (from-to)S221-S237
Number of pages17
JournalJournal of Alzheimer's Disease
Publication statusPublished - 13 Aug 2019


  • Alzheimer's disease
  • clinical trial
  • cognitive decline
  • cognitive training
  • dementia
  • depression
  • non-pharmacological
  • nutrition
  • physical activity
  • randomized controlled trial

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