Main Group Metal-Mediated Transformations of Imines

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Abstract

Main-group-metal-mediated transformations of imines have earned a valued place in the synthetic chemist's toolbox. Their versatility allows the simple preparation of various nitrogen containing compounds. This review will outline the early discoveries including metallation, addition/cyclisation and metathesis pathways, followed by the modern-day use of imines in synthetic methodology. Recent advances in imine C−F activation protocols are discussed, alongside revisiting “classic” imine reactivity from a sustainable perspective. Developments in catalytic methods for hydroelementation of imines have been reviewed, highlighting the importance of s-block metals in the catalytic arena. Whilst stoichiometric transformations in alternative reaction media such as deep eutectic solvents or water have been summarised. The incorporation of imines into flow chemistry has received recent attention and is summarised within.

Original languageEnglish
Pages (from-to)2569-2588
Number of pages20
JournalChemistry - A European Journal
Volume27
Issue number8
DOIs
Publication statusPublished - 5 Feb 2021

Keywords

  • addition
  • catalysis
  • C−F activation
  • imines
  • metallation

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